{"title":"Biosynthesis of UDP-GlcA: Via UDPGDH or the myo- inositol oxidation pathway?","authors":"A. Kärkönen","doi":"10.1080/11263500500056161","DOIUrl":null,"url":null,"abstract":"UDP-d-glucuronic acid (UDP-GlcA) is a key intermediate in the synthesis of other UDP-sugars and also an important glucuronosyl donor for cell wall polysaccharide synthesis. UDP-GlcA can be synthesised via two routes in plants: the myo-inositol oxidation pathway and a pathway involving UDP-glucose dehydrogenase (UDPGDH)-catalysed oxidation of UDP-glucose (UDP-Glc). This review discusses the synthesis of UDPGlcA within the context of cell wall biosynthesis.","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2005-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/11263500500056161","citationCount":"14","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1080/11263500500056161","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 14
Abstract
UDP-d-glucuronic acid (UDP-GlcA) is a key intermediate in the synthesis of other UDP-sugars and also an important glucuronosyl donor for cell wall polysaccharide synthesis. UDP-GlcA can be synthesised via two routes in plants: the myo-inositol oxidation pathway and a pathway involving UDP-glucose dehydrogenase (UDPGDH)-catalysed oxidation of UDP-glucose (UDP-Glc). This review discusses the synthesis of UDPGlcA within the context of cell wall biosynthesis.
期刊介绍:
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.