Glycosylation employing glycopyranosyl fluorides promoted by TiF4 under mild conditions

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2020-01-01 DOI:10.1080/07328303.2020.1837151

Joachim Thiem , Matthias Wiesner

引用次数: 0

Abstract

Glycopyranosyl fluorides are shown as efficient glycosyl donors by glycosylation of appropriate aglycon structures under mild conditions with Lewis acid catalysis in anhydrous ether or acetonitrile. Further direct reaction sequences gave naturally occurring disaccharide derivatives of biological interest.

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在温和条件下，TiF4促进甘氨酰氟的糖基化

在温和的条件下，在无水醚或乙腈中，通过Lewis酸催化适当的糖基化，甘氨酰氟化物被证明是有效的糖基供体。进一步的直接反应序列产生了具有生物学意义的天然双糖衍生物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.