Predictive values of metabolic score for insulin resistance on risk of major adverse cardiovascular events and comparison with other insulin resistance indices among Chinese with and without diabetes mellitus: Results from the 4C cohort study

IF 3.2 3区 医学
Limeng Pan, Huajie Zou, Xiaoyu Meng, Danpei Li, Wenjun Li, Xi Chen, Yan Yang, Xuefeng Yu
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引用次数: 2

Abstract

Aims/Introduction

To investigate the relationship between the metabolic score for insulin resistance (METS-IR) index and major adverse cardiac events (MACEs) and to compare its ability to predict MACEs with other IR indices including homeostatic model assessment for IR (HOMA-IR) and triglyceride glucose (TyG) index-related parameters.

Materials and Methods

We conducted a cohort study enrolling 7,291 participants aged ≥40 years. Binary logistic regression and restricted cubic splines were performed to determine the association between METS-IR and MACEs, and the receiver operating curve (ROC) was utilized to compare the predictive abilities of IR indices and to determine the optimal cut-off points.

Results

There were 348 (4.8%) cases of MACEs during a median follow-up of 3.8 years. Compared with participants with a METS-IR in the lowest quartile, the multivariate-adjusted RRs and 95% CIs for participants with a METS-IR in the highest quartile were 1.47 (1.05–2.77) in all participants, 1.42 (1.18–2.54) for individuals without diabetes, and 1.75 (1.11–6.46) for individuals with diabetes. Significant interactions were found between the METS-IR and the risk of MACEs by sex in all participants and by age and sex in individuals without diabetes (all P values for interaction < 0.05). In the ROC analysis, the METS-IR had a higher AUC value than other indices for predicting MACEs in individuals with diabetes and had a comparable or higher AUC than other indices for individuals without diabetes.

Conclusions

The METS-IR can be an effective clinical indicator for identifying MACEs, as it had superior predictive power when compared with other IR indices in individuals with diabetes.

胰岛素抵抗代谢评分对中国糖尿病患者和非糖尿病患者主要心血管不良事件风险的预测价值及与其他胰岛素抵抗指标的比较:来自4C队列研究的结果
目的/简介探讨胰岛素抵抗代谢评分(METS-IR)指数与主要心脏不良事件(mace)的关系,并比较其与其他IR指标(包括IR稳态模型评估(HOMA-IR)和甘油三酯葡萄糖(TyG)指数相关参数)预测主要心脏不良事件(mace)的能力。材料和方法我们进行了一项队列研究,纳入了7291名年龄≥40岁的参与者。采用二元logistic回归和受限三次样条法确定met -IR与mace的相关性,采用受试者工作曲线(receiver operating curve, ROC)比较IR指标的预测能力并确定最佳截断点。结果中位随访3.8年,共发生mace 348例(4.8%)。与met - ir最低四分位数的参与者相比,met - ir最高四分位数的参与者的多变量调整后的rr和95% ci为1.47(1.05-2.77),非糖尿病个体为1.42(1.18-2.54),糖尿病个体为1.75(1.11-6.46)。发现met - ir与所有参与者的性别和非糖尿病个体的年龄和性别之间存在显著的相互作用(相互作用的P值均为0.05)。在ROC分析中,在预测糖尿病患者mace方面,METS-IR的AUC值高于其他指标,而在预测非糖尿病患者mace方面,METS-IR的AUC值与其他指标相当或更高。结论与其他IR指标相比,METS-IR在糖尿病患者中具有更强的预测能力,可作为诊断mace的有效临床指标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Diabetes Investigation
Journal of Diabetes Investigation Medicine-Internal Medicine
自引率
9.40%
发文量
218
期刊介绍: Journal of Diabetes Investigation is your core diabetes journal from Asia; the official journal of the Asian Association for the Study of Diabetes (AASD). The journal publishes original research, country reports, commentaries, reviews, mini-reviews, case reports, letters, as well as editorials and news. Embracing clinical and experimental research in diabetes and related areas, the Journal of Diabetes Investigation includes aspects of prevention, treatment, as well as molecular aspects and pathophysiology. Translational research focused on the exchange of ideas between clinicians and researchers is also welcome. Journal of Diabetes Investigation is indexed by Science Citation Index Expanded (SCIE).
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