Effects of the carbonate content in carbonate apatite on bone replacement

IF 3.1 3区生物学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Journal of Tissue Engineering and Regenerative Medicine Pub Date : 2021-11-29 DOI:10.1002/term.3270

Kaai Deguchi, Shunsuke Nomura, Akira Tsuchiya, Ichiro Takahashi, Kunio Ishikawa

引用次数: 8

Abstract

Carbonate apatite (CO₃Ap), an inorganic component of human bone, has been clinically applied as an artificial bone substitute. In this study, the effects of the CO₃ content in CO₃Ap on the replacement by new bone were studied by fabricating CO₃Ap granules containing 0.9–8.3 wt% of CO₃. The dissolution rate of CO₃Ap in a weak acidic solution, mimicking the Howship's lacunae, was rapid for the CO₃Ap granules containing a larger amount of CO₃. Histological analyses demonstrated the rapid resorption in CO₃Ap and replacement by natural bone tissue when the CO₃ content was increased. Therefore, the CO₃ content in CO₃Ap is a key factor that influences the replacement of the bone tissue.

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碳酸盐磷灰石中碳酸盐含量对骨置换的影响

碳酸钙磷灰石(CO3Ap)是一种人体骨骼的无机成分，已被临床应用于人工骨替代品。本研究通过制备CO3Ap颗粒，研究CO3Ap中CO3含量对新骨置换的影响，CO3Ap颗粒中CO3含量为0.9-8.3 wt%。CO3Ap颗粒中CO3含量较大，在弱酸性溶液中，CO3Ap的溶解速度较快，模拟了Howship氏腔隙。组织学分析表明，当CO3含量增加时，CO3Ap被快速吸收并被天然骨组织取代。因此，CO3Ap中CO3含量是影响骨组织置换的关键因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Tissue Engineering and Regenerative Medicine 生物-工程：生物医学

CiteScore

7.50

自引率

3.00%

发文量

审稿时长

4-8 weeks

期刊介绍： Journal of Tissue Engineering and Regenerative Medicine publishes rapidly and rigorously peer-reviewed research papers, reviews, clinical case reports, perspectives, and short communications on topics relevant to the development of therapeutic approaches which combine stem or progenitor cells, biomaterials and scaffolds, growth factors and other bioactive agents, and their respective constructs. All papers should deal with research that has a direct or potential impact on the development of novel clinical approaches for the regeneration or repair of tissues and organs. The journal is multidisciplinary, covering the combination of the principles of life sciences and engineering in efforts to advance medicine and clinical strategies. The journal focuses on the use of cells, materials, and biochemical/mechanical factors in the development of biological functional substitutes that restore, maintain, or improve tissue or organ function. The journal publishes research on any tissue or organ and covers all key aspects of the field, including the development of new biomaterials and processing of scaffolds; the use of different types of cells (mainly stem and progenitor cells) and their culture in specific bioreactors; studies in relevant animal models; and clinical trials in human patients performed under strict regulatory and ethical frameworks. Manuscripts describing the use of advanced methods for the characterization of engineered tissues are also of special interest to the journal readership.