The effect of depressive symptoms on disability-free survival in healthy older adults: A prospective cohort study

IF 5.3 2区医学 Q1 PSYCHIATRY

Acta Psychiatrica Scandinavica Pub Date : 2022-10-25 DOI:10.1111/acps.13513

Greg Roebuck, Mojtaba Lotfaliany, Bruno Agustini, Malcolm Forbes, Mohammadreza Mohebbi, John McNeil, Robyn L. Woods, Christopher M. Reid, Mark R. Nelson, Raj C. Shah, Joanne Ryan, Anne B. Newman, Alice Owen, Rosanne Freak-Poli, Nigel Stocks, Michael Berk, ASPREE Investigator Group

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引用次数: 3

Abstract

Background

Gerontology and ageing research are increasingly focussing on healthy life span (healthspan), the period of life lived free of serious disease and disability. Late-life depression (LLD) is believed to impact adversely on physical health. However, no studies have examined its effect on healthspan. This study investigated the effect of LLD and subthreshold depression on disability-free survival, a widely accepted measure of healthspan.

Methods

This prospective cohort study used data from the ASPirin in Reducing Events in the Elderly study. Participants were aged ≥70 years (or ≥65 years for African-American and Hispanic participants) and free of dementia, physical disability and cardiovascular disease. Depressive symptoms were measured using the 10-item Centre for Epidemiological Studies Depression Scale (CES-D-10). LLD and subthreshold depression were defined as CES-D-10 scores ≥8 and 3–7, respectively. Disability-free survival was defined as survival free of dementia and persistent physical disability.

Results

A total of 19,110 participants were followed up for a maximum of 7.3 years. In female participants, LLD was associated with lower disability-free survival adjusting for sociodemographic and lifestyle factors, medical comorbidities, polypharmacy, physical function and antidepressant use (HR, 1.50; 95% CI, 1.23–1.82). In male participants, LLD was associated with lower disability-free survival adjusting for sociodemographic and lifestyle factors (HR, 1.30; 95% CI, 1.03–1.64). Subthreshold depression was also associated with lower disability-free survival in both sexes.

Conclusions

LLD may be a common and important risk factor for shortened healthspan.

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抑郁症状对健康老年人无残疾生存的影响:一项前瞻性队列研究

老年学和老龄化研究越来越关注健康寿命(healthspan)，即没有严重疾病和残疾的寿命。老年抑郁症(LLD)被认为对身体健康产生不利影响。然而，没有研究调查过它对健康寿命的影响。本研究调查了LLD和阈下抑郁对无残疾生存的影响，无残疾生存是一种被广泛接受的健康跨度衡量标准。方法:这项前瞻性队列研究使用了阿司匹林在减少老年事件研究中的数据。参与者年龄≥70岁(非裔美国人和西班牙裔参与者≥65岁)，无痴呆、身体残疾和心血管疾病。采用10项流行病学研究中心抑郁量表(CES-D-10)测量抑郁症状。ce - d -10评分≥8分和3-7分分别定义为LLD和阈下抑郁。无残疾生存期定义为无痴呆和持续性身体残疾的生存期。结果共对19110名参与者进行了最长7.3年的随访。在女性参与者中，LLD与较低的无残疾生存率相关，调整了社会人口统计学和生活方式因素、医疗合并症、多种药物、身体功能和抗抑郁药的使用(HR, 1.50;95% ci, 1.23-1.82)。在男性参与者中，LLD与较低的无残疾生存率相关(HR, 1.30;95% ci, 1.03-1.64)。阈下抑郁在两性中也与较低的无残疾生存率相关。结论低密度脂蛋白可能是健康寿命缩短的重要危险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Psychiatrica Scandinavica 医学-精神病学

CiteScore

11.20

自引率

3.00%

发文量

135

审稿时长

6-12 weeks

期刊介绍： Acta Psychiatrica Scandinavica acts as an international forum for the dissemination of information advancing the science and practice of psychiatry. In particular we focus on communicating frontline research to clinical psychiatrists and psychiatric researchers. Acta Psychiatrica Scandinavica has traditionally been and remains a journal focusing predominantly on clinical psychiatry, but translational psychiatry is a topic of growing importance to our readers. Therefore, the journal welcomes submission of manuscripts based on both clinical- and more translational (e.g. preclinical and epidemiological) research. When preparing manuscripts based on translational studies for submission to Acta Psychiatrica Scandinavica, the authors should place emphasis on the clinical significance of the research question and the findings. Manuscripts based solely on preclinical research (e.g. animal models) are normally not considered for publication in the Journal.