Early life factors and hippocampal functional connectivity in children with overweight/obesity

IF 2.7 3区医学 Q1 PEDIATRICS

Pediatric Obesity Pub Date : 2022-12-27 DOI:10.1111/ijpo.12998

Patricio Solis-Urra, Irene Esteban-Cornejo, Jose Mora-Gonzalez, Chelsea Stillman, Oren Contreras-Rodriguez, Kirk I. Erickson, Andrés Catena, Francisco B. Ortega

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引用次数: 1

Abstract

Objective

We investigated the association of anthropometric neonatal data (birth length and birth weight) and breastfeeding practices (exclusive and any breastfeeding) with hippocampal functional connectivity and its academic implication in children with overweight/obesity.

Methods

Ninety six children with overweight/obesity aged 8–11 years (10.01 ± 1.14), from the ActiveBrains project were included in this cross-sectional study. Anthropometric neonatal data were collected from birth records, whereas breastfeeding practices were reported by parents. A 3.0 Tesla Siemens Magnetom Tim Trio system was used to acquire T1-weighted and resting-state functional magnetic resonance images. Academic performance was assessed by the Woodcock-Muñoz standardized test. Hippocampal seed-based methods with post-hoc regression analyses were performed. Analyses were considered significant when surpassing Family-Wise Error corrections.

Results

Birth weight showed a positive association with the connectivity between the hippocampus and the pre- and postcentral gyri, and the cerebellum. In addition, breastfeeding was negatively associated with the connectivity between the hippocampus and the primary motor cortex and the angular gyrus. Any breastfeeding, in turn, showed a positive association with the connectivity between the hippocampus and the middle temporal gyrus. None of the connectivity outcomes related to early life factors was coupled with better academic abilities (all p > 0.05).

Conclusions

Our findings suggest that birth weight at birth and breastfeeding are associated with hippocampal connectivity in children with overweight/obesity. Despite this, how the results relate to academic performance remains a matter of speculation. Our findings suggest that clinicians should recognize the importance early life factors for potentially avoiding consequences on offspring's brain development.

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超重/肥胖儿童的早期生活因素与海马功能连通性

目的研究新生儿人体测量数据(出生长度和出生体重)和母乳喂养(纯母乳喂养和任何母乳喂养)与超重/肥胖儿童海马功能连通性的关系及其学术意义。方法选取来自ActiveBrains项目的96例8 ~ 11岁超重/肥胖儿童(10.01±1.14)为研究对象。新生儿的人体测量数据是从出生记录中收集的，而母乳喂养的做法则由父母报告。采用3.0 Tesla Siemens Magnetom Tim Trio系统获取t1加权静息态功能磁共振图像。学业成绩通过Woodcock-Muñoz标准化测试进行评估。采用基于海马种子的方法进行事后回归分析。当超过家庭错误修正时，分析被认为是重要的。结果出生体重与海马、中央前回、中央后回和小脑的连通性呈正相关。此外，母乳喂养与海马体、初级运动皮层和角回之间的连通性呈负相关。反过来，任何母乳喂养都显示出与海马体和中颞回之间的联系呈正相关。与早期生活因素相关的连通性结果与更好的学术能力无关(均p > 0.05)。结论:我们的研究结果表明，出生体重和母乳喂养与超重/肥胖儿童的海马连通性有关。尽管如此，这些结果与学习成绩之间的关系仍然是一个猜测问题。我们的研究结果表明，临床医生应该认识到早期生活因素的重要性，以潜在地避免对后代大脑发育造成影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Obesity PEDIATRICS-

CiteScore

7.30

自引率

5.30%

发文量

117

审稿时长

6-12 weeks

期刊介绍： Pediatric Obesity is a peer-reviewed, monthly journal devoted to research into obesity during childhood and adolescence. The topic is currently at the centre of intense interest in the scientific community, and is of increasing concern to health policy-makers and the public at large. Pediatric Obesity has established itself as the leading journal for high quality papers in this field, including, but not limited to, the following: Genetic, molecular, biochemical and physiological aspects of obesity – basic, applied and clinical studies relating to mechanisms of the development of obesity throughout the life course and the consequent effects of obesity on health outcomes Metabolic consequences of child and adolescent obesity Epidemiological and population-based studies of child and adolescent overweight and obesity Measurement and diagnostic issues in assessing child and adolescent adiposity, physical activity and nutrition Clinical management of children and adolescents with obesity including studies of treatment and prevention Co-morbidities linked to child and adolescent obesity – mechanisms, assessment, and treatment Life-cycle factors eg familial, intrauterine and developmental aspects of child and adolescent obesity Nutrition security and the "double burden" of obesity and malnutrition Health promotion strategies around the issues of obesity, nutrition and physical activity in children and adolescents Community and public health measures to prevent overweight and obesity in children and adolescents.