Influence of hepatitis B virus on the prevalence of diabetes complications in patients with type 2 diabetes

IF 3 3区医学

Journal of Diabetes Investigation Pub Date : 2022-12-12 DOI:10.1111/jdi.13954

Xi-yu Liu, Yan Zhou

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引用次数: 0

Abstract

Aims/Introduction

Diabetes and hepatitis B are both global problems. The influence of diabetes on complications and prognosis of hepatitis B has been widely studied. However, the association between hepatitis B virus (HBV) infection and the prevalence of diabetes-related complications is less documented and is uncertain.

Materials and Methods

This was a retrospective study. We collected information from a large clinical database. A total of 1,090 Chinese inpatients with type 2 diabetes were included.

Results

The participants were divided into two groups, including 135 patients with HBV infection and 955 patients without HBV infection. Patients with HBV infection were younger and had worse control of blood glucose than those without HBV infection. No significant difference was found in the prevalence of diabetic retinopathy, neuropathy, nephropathy, diabetic ketosis or diabetic ketoacidosis between the patients with HBV infection and the patients without HBV infection. The prevalence of macrovascular complications was 54.1% and 64.4% in diabetes patients complicated with HBV infection and without HBV infection, respectively. The P-value was <0.05. However, through the logistic regression analysis, we found HBV infection was not an independent risk factor for macrovascular complications of diabetes.

Conclusion

There was no significant correlation between the prevalence of macrovascular complications, microvascular complications of diabetes, diabetic ketosis or diabetic ketoacidosis and HBV infection status.

Abstract Image

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乙型肝炎病毒对2型糖尿病患者糖尿病并发症患病率的影响

糖尿病和乙型肝炎都是全球性问题。糖尿病对乙型肝炎并发症及预后的影响已被广泛研究。然而，乙型肝炎病毒(HBV)感染与糖尿病相关并发症患病率之间的关联文献较少，且不确定。材料与方法本研究为回顾性研究。我们从一个大型临床数据库中收集信息。共纳入1090名中国2型糖尿病住院患者。结果研究对象分为两组，HBV感染患者135例，无HBV感染患者955例。HBV感染患者较无HBV感染患者年龄小，血糖控制较差。在糖尿病视网膜病变、神经病变、肾病、糖尿病酮症、糖尿病酮症酸中毒患病率方面，HBV感染患者与未感染患者无显著差异。合并HBV感染的糖尿病患者大血管并发症发生率为54.1%，未感染的糖尿病患者大血管并发症发生率为64.4%。p值为0.05。然而，通过logistic回归分析，我们发现HBV感染并不是糖尿病大血管并发症的独立危险因素。结论糖尿病大血管并发症、微血管并发症、糖尿病酮症、糖尿病酮症酸中毒发生率与HBV感染状况无显著相关性。

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来源期刊

Journal of Diabetes Investigation Medicine-Internal Medicine

自引率

9.40%

发文量

218

期刊介绍： Journal of Diabetes Investigation is your core diabetes journal from Asia; the official journal of the Asian Association for the Study of Diabetes (AASD). The journal publishes original research, country reports, commentaries, reviews, mini-reviews, case reports, letters, as well as editorials and news. Embracing clinical and experimental research in diabetes and related areas, the Journal of Diabetes Investigation includes aspects of prevention, treatment, as well as molecular aspects and pathophysiology. Translational research focused on the exchange of ideas between clinicians and researchers is also welcome. Journal of Diabetes Investigation is indexed by Science Citation Index Expanded (SCIE).