Microfluidic Templated Stem Cell Spheroid Microneedles for Diabetic Wound Treatment

IF 26.8 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Advanced Materials Pub Date : 2023-04-24 DOI:10.1002/adma.202301064

Xiangyi Wu, Danqing Huang, Ye Xu, Guopu Chen, Yuanjin Zhao

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引用次数: 7

Abstract

Wound dressing patches based on stem cells have demonstrated promising potential in the treatment of diabetic wounds, while their capabilities in the maintenance of cell stemness, effective exchange of cellular substance, and precise targeting of the stem cells remain to be promoted. Here, a novel stem cell spheroid loaded microneedle (MN@SPs) patch is presented using microfluidic templating technology. By leveraging the precise fluid manipulation capabilities of the microfluidic template, stem cell spheroids (SPs) with uniform size can be generated in situ. The resulting SPs exhibit advanced viability and cell functions, as evidenced by the overexpressed genes related to extracellular matrix organization and angiogenesis. By loading these SPs into the microneedles (MNs), the platform enables the precise delivery and exchange of multiple active substances, which contribute to advanced neovascularization, collagen deposition, and tissue reconstruction of diabetic wounds. Overall, this microfluidic-engineered stem cell therapy platform demonstrates significant promise in promoting wound healing.

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微流控模板干细胞球形微针用于糖尿病伤口治疗

基于干细胞的创面贴在糖尿病创面的治疗中已显示出良好的潜力，但其在维持细胞干细胞性、有效交换细胞物质和精确靶向干细胞方面的能力仍有待提高。本文采用微流控模板技术，提出了一种新型干细胞球形微针贴片(MN@SPs)。通过利用微流控模板的精确流体操纵能力，可以原位生成具有均匀大小的干细胞球体(SPs)。通过过度表达与细胞外基质组织和血管生成相关的基因，结果表明SPs具有先进的活力和细胞功能。通过将这些SPs加载到微针(MNs)中，该平台实现了多种活性物质的精确递送和交换，有助于糖尿病伤口的晚期新生血管、胶原沉积和组织重建。总的来说，这种微流体工程干细胞治疗平台在促进伤口愈合方面显示出巨大的希望。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced Materials 工程技术-材料科学：综合

CiteScore

43.00

自引率

4.10%

发文量

2182

审稿时长

2 months

期刊介绍： Advanced Materials, one of the world's most prestigious journals and the foundation of the Advanced portfolio, is the home of choice for best-in-class materials science for more than 30 years. Following this fast-growing and interdisciplinary field, we are considering and publishing the most important discoveries on any and all materials from materials scientists, chemists, physicists, engineers as well as health and life scientists and bringing you the latest results and trends in modern materials-related research every week.