Red wine polyphenols reverse depressive-like behaviors in mice induced by repeated corticosterone treatment

IF 1.1 4区农林科学 Q4 FOOD SCIENCE & TECHNOLOGY

Ciencia E Tecnica Vitivinicola Pub Date : 2019-01-01 DOI:10.1051/ctv/201934020115

Tingxu Yan, Yingying Sun, Bo Wu, Feng Xiao, Kaishun Bi, Baoshan Sun, Ying Jia

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引用次数: 1

Abstract

The aim of this study was to investigate the antidepressant-like effect of red wine phenolic extracts in mouse model exposed to exogenous corticosterone. The results showed that 3-week corticosterone injections caused depression-like behavior in mice, as indicated by the significant decrease in sucrose consumption and increase immobility time in the forced swimming test (FST). Red wine phenolic extracts treatment significantly reduced serum corticosterone levels. Moreover, it was found that red wine phenolic extract increased the brain-derived neurotrophic factor protein (BNDF) and tropomyosin-related kinase B (TrkB) phosphorylation and cAMP-responsive element binding protein (CREB) phosphorylation levels in the hippocampus and prefrontal cortex. However, K252a, an inhibitor of TrkB, completely abolished those antidepressant-like effects. These results suggested that the red wine phenolic extracts produce an antidepressant-like effect in corticosteronetreated mice, at least in part, which is possibly mediated by modulating hypothalamic-pituitary-adrenal (HPA) axis, BDNF, TrkB and CREB phosphorylation levels in the brain region of mice.

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红酒多酚能逆转由皮质酮反复治疗引起的小鼠抑郁样行为

本研究旨在探讨外源性皮质酮暴露小鼠模型中红酒酚类提取物的抗抑郁作用。结果显示，3周皮质酮注射可引起小鼠抑郁样行为，如强迫游泳试验(FST)中糖消耗显著减少和静止时间增加。红酒酚提取物显著降低血清皮质酮水平。此外，还发现红酒酚提取物增加了海马和前额叶皮层脑源性神经营养因子蛋白(BNDF)和原肌球蛋白相关激酶B (TrkB)磷酸化和camp响应因子结合蛋白(CREB)磷酸化水平。然而，TrkB抑制剂K252a完全消除了这些抗抑郁样作用。这些结果表明，红葡萄酒酚提取物在皮质类固醇治疗小鼠中产生类似抗抑郁的作用，至少部分是通过调节下丘脑-垂体-肾上腺(HPA)轴，BDNF, TrkB和CREB磷酸化水平在小鼠的大脑区域。

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来源期刊

Ciencia E Tecnica Vitivinicola Agricultural and Biological Sciences-Food Science

自引率

12.50%

发文量

期刊介绍： Ciência e Técnica Vitivinícola (Journal of Viticulture and Enology) is an international journal that publishes original articles, research notes and review articles, written in Portuguese or in English, on the various fields of the science and technology of vine and wine: Viticulture, Enology and Vitivinicultural economy.