Endocrine-disrupting chemicals, risk of type 2 diabetes, and diabetes-related metabolic traits: A systematic review and meta-analysis

IF 3 2区医学 Q2 ENDOCRINOLOGY & METABOLISM

Journal of Diabetes Pub Date : 2015-06-29 DOI:10.1111/1753-0407.12325

Yan Song, Elizabeth L. Chou, Aileen Baecker, Nai-Chieh Y. You, Yiqing Song, Qi Sun, Simin Liu

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引用次数: 145

Abstract

Background

Elevated blood or urinary concentrations of endocrine-disrupting chemicals (EDCs) may be related to increased risk of type 2 diabetes (T2D). The aim of the present study was to assess the role of EDCs in affecting risk of T2D and related metabolic traits.

Methods

MEDLINE was searched for cross-sectional and prospective studies published before 8 March 2014 into the association between EDCs (dioxin, polychlorinated biphenyl [PCB], chlorinated pesticide, bisphenol A [BPA], phthalate) and T2D and related metabolic traits. Three investigators independently extracted information on study design, participant characteristics, EDC types and concentrations, and association measures.

Results

Forty-one cross-sectional and eight prospective studies from ethnically diverse populations were included in the analysis. Serum concentrations of dioxins, PCBs, and chlorinated pesticides were significantly associated with T2D risk; comparing the highest to lowest concentration category, the pooled relative risks (RR) were 1.91 (95% confidence interval [CI] 1.44–2.54) for dioxins, 2.39 (95% CI 1.86–3.08) for total PCBs, and 2.30 (95% CI 1.81–2.93) for chlorinated pesticides. Urinary concentrations of BPA and phthalates were also associated with T2D risk; comparing the highest to lowest concentration categories, the pooled RR were 1.45 (95% CI 1.13–1.87) for BPA and 1.48 (95% CI 0.98–2.25) for phthalates. Further, EDC concentrations were associated with indicators of impaired fasting glucose and insulin resistance.

Conclusions

Persistent and non-persistent EDCs may affect the risk of T2D. There is an urgent need for further investigation of EDCs, especially non-persistent ones, and T2D risk in large prospective studies.

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内分泌干扰物、2型糖尿病风险和糖尿病相关代谢特征:系统综述和荟萃分析

背景:血液或尿液中内分泌干扰物(EDCs)浓度升高可能与2型糖尿病(T2D)风险增加有关。本研究的目的是评估EDCs在影响T2D风险和相关代谢特征中的作用。方法MEDLINE检索2014年3月8日之前发表的关于EDCs(二恶英、多氯联苯、氯化农药、双酚A、邻苯二甲酸酯)与T2D及相关代谢性状相关性的横断面和前瞻性研究。三位研究者独立提取了研究设计、参与者特征、EDC类型和浓度以及关联测量的信息。结果来自不同种族人群的41项横断面研究和8项前瞻性研究被纳入分析。血清二恶英、多氯联苯和氯化农药浓度与T2D风险显著相关;对最高和最低浓度类别进行比较，二恶英的总相对危险度(RR)为1.91(95%可信区间[CI] 1.44-2.54)，多氯联苯的总相对危险度(RR)为2.39(95%可信区间[CI] 1.86-3.08)，氯化农药的总相对危险度(RR)为2.30 (95% CI 1.81-2.93)。尿中BPA和邻苯二甲酸盐浓度也与T2D风险相关;比较最高和最低浓度类别，双酚a的合并RR为1.45 (95% CI 1.13-1.87)，邻苯二甲酸酯的合并RR为1.48 (95% CI 0.98-2.25)。此外，EDC浓度与空腹血糖受损和胰岛素抵抗指标相关。结论持续性和非持续性EDCs可能影响T2D的发生风险。迫切需要在大型前瞻性研究中进一步研究EDCs，特别是非持续性EDCs和T2D风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Diabetes ENDOCRINOLOGY & METABOLISM-

CiteScore

6.50

自引率

2.20%

发文量

审稿时长

>12 weeks

期刊介绍： Journal of Diabetes (JDB) devotes itself to diabetes research, therapeutics, and education. It aims to involve researchers and practitioners in a dialogue between East and West via all aspects of epidemiology, etiology, pathogenesis, management, complications and prevention of diabetes, including the molecular, biochemical, and physiological aspects of diabetes. The Editorial team is international with a unique mix of Asian and Western participation. The Editors welcome submissions in form of original research articles, images, novel case reports and correspondence, and will solicit reviews, point-counterpoint, commentaries, editorials, news highlights, and educational content.

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