Association of the triglyceride-glucose index with subclinical left ventricular dysfunction in type 2 diabetes mellitus patients: A retrospective cross-sectional study

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2023-05-07 DOI:10.1111/jdi.14026

Qi-chao Sun, Jie Liu, Ran Meng, Ning Zhang, Jing Yao, Fan Yang, Da-long Zhu

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引用次数: 5

Abstract

Aims/Introduction

The triglyceride-glucose (TyG) index is a simple and reliable indicator of insulin resistance, and is associated with the development and poor outcomes of cardiovascular disease. Subclinical left ventricular dysfunction (SLVD) is frequently detected in approximately one-third of diabetes patients, but it has not been established whether the TyG index correlates with SLVD. We carried out this research to evaluate the relationship between the TyG index and SLVD in type 2 diabetes mellitus patients.

Materials and Methods

This was a cross-sectional and observational study of 183 type 2 diabetes mellitus inpatients at Nanjing Drum Tower Hospital, Nanjing, China. The TyG index and homeostasis model assessment 2 estimates for insulin resistance (HOMA2-IR) were calculated from biochemical measurements, and speckle-tracking echocardiography was carried out. According to global longitudinal strain (GLS) by echocardiography, participants were categorized into the SLVD (GLS <18%) group or the non-SLVD (GLS ≥18%) group.

Results

In comparison with non-SLVD participants, SLVD participants had higher insulin resistance, as reflected by elevated TyG and HOMA2-IR indices, as well as a higher body mass index, waist circumference and triglyceride level (P < 0.05 for each). When grouped by TyG index tertiles, an elevated TyG index was correlated with other cardiometabolic risk factors, as well as a decrease in GLS. In the multivariate logistic regression analyses, the TyG index was an independent risk factor for SLVD in type 2 diabetes mellitus patients (odds ratio 2.047, 95% confidence interval 1.07–3.914, P = 0.03), whereas HOMA2-IR was not.

Conclusions

The TyG index is independently associated with SLVD in type 2 diabetes mellitus patients and is a more reliable indicator of SLVD than HOMA2-IR.

Abstract Image

查看原文本刊更多论文

2型糖尿病患者甘油三酯-葡萄糖指数与亚临床左心室功能障碍的关系:一项回顾性横断面研究

甘油三酯-葡萄糖(TyG)指数是一种简单可靠的胰岛素抵抗指标，与心血管疾病的发展和不良结局相关。亚临床左心室功能障碍(SLVD)在大约三分之一的糖尿病患者中经常被检测到，但TyG指数是否与SLVD相关尚未确定。本研究旨在评价2型糖尿病患者TyG指数与SLVD的关系。材料与方法对中国南京市鼓楼医院住院的183例2型糖尿病患者进行横断面观察性研究。通过生化测量计算胰岛素抵抗的TyG指数和稳态模型评估2 (HOMA2-IR)，并进行斑点跟踪超声心动图。根据超声心动图的全局纵向应变(GLS)，将受试者分为SLVD组(GLS≥18%)和非SLVD组(GLS≥18%)。结果与非SLVD组相比，SLVD组胰岛素抵抗更高，TyG和HOMA2-IR指数升高，体重指数、腰围和甘油三酯水平均较高(P < 0.05)。当按TyG指数分类时，TyG指数升高与其他心脏代谢危险因素以及GLS降低相关。在多因素logistic回归分析中，TyG指数是2型糖尿病患者SLVD的独立危险因素(优势比2.047,95%可信区间1.07-3.914,P = 0.03)，而HOMA2-IR不是。结论TyG指数与2型糖尿病患者SLVD独立相关，是比HOMA2-IR更可靠的SLVD指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Diabetes Investigation Medicine-Internal Medicine

自引率

9.40%

发文量

218

期刊介绍： Journal of Diabetes Investigation is your core diabetes journal from Asia; the official journal of the Asian Association for the Study of Diabetes (AASD). The journal publishes original research, country reports, commentaries, reviews, mini-reviews, case reports, letters, as well as editorials and news. Embracing clinical and experimental research in diabetes and related areas, the Journal of Diabetes Investigation includes aspects of prevention, treatment, as well as molecular aspects and pathophysiology. Translational research focused on the exchange of ideas between clinicians and researchers is also welcome. Journal of Diabetes Investigation is indexed by Science Citation Index Expanded (SCIE).