Depressive symptoms and mortality-findings from Helsinki birth cohort study

IF 5.3 2区医学 Q1 PSYCHIATRY

Acta Psychiatrica Scandinavica Pub Date : 2022-10-20 DOI:10.1111/acps.13512

Mia D. Eriksson, Johan G. Eriksson, P?ivi Korhonen, Hannu Koponen, Minna K. Salonen, Tuija M. Mikkola, Eero Kajantie, Niko S. Wasenius, Mikaela von Bonsdorff, Hannu Kautiainen, Merja K. Laine

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引用次数: 1

Abstract

Background

Individuals with depression and depressive symptoms have a higher mortality rate than non-depressed individuals. The increased comorbidity and mortality associated with depression has remained largely unexplained. The underlying pathophysiological differences between depressive subtypes, melancholic and non-melancholic, may provide some explanation to this phenomenon.

Methods

One thousand nine hundred and ninety five participants (mean age 61 years) from the Helsinki Birth Cohort Study were recruited for this prospective study and followed up for a mean of 14.1 years. Information regarding medical history, lifestyle, and biochemical parameters were obtained. Depressive symptoms were assessed using the Beck Depression Inventory. Standardized mortality ratios were calculated.

Results

Participants were followed up for a total of 28,044 person-years. The melancholic depressive group had an increased adjusted risk of mortality [HR 1.49 (95% CI: 1.02–2.20)] when compared to the non-depressive group. Comparing mortality to the whole population of Finland using standardized mortality ratios (SMR) both the non-melancholic [1.11 (95% CI: 0.85–1.44)] and melancholic depressive [1.26 (95% CI: 0.87–1.81)] groups had higher mortality than the non-depressive group [0.82 (95% CI: 0.73–0.93)].

Conclusions

Melancholic depressive symptoms are most strongly related to a higher mortality risk.

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抑郁症状和死亡率——来自赫尔辛基出生队列研究的发现

背景:患有抑郁症和抑郁症状的人比没有抑郁症的人死亡率更高。与抑郁症相关的合并症和死亡率的增加在很大程度上仍未得到解释。抑郁亚型(抑郁型和非抑郁型)之间潜在的病理生理差异可能为这一现象提供了一些解释。方法从赫尔辛基出生队列研究中招募了995名参与者(平均年龄61岁)进行这项前瞻性研究，平均随访14.1年。获得有关病史、生活方式和生化参数的信息。使用贝克抑郁量表评估抑郁症状。计算标准化死亡率。结果参与者共随访28,044人年。与非抑郁组相比，忧郁抑郁组的调整死亡率风险增加[HR 1.49 (95% CI: 1.02-2.20)]。使用标准化死亡率(SMR)与芬兰全体人口的死亡率进行比较，非抑郁组[1.11 (95% CI: 0.85-1.44)]和抑郁抑郁组[1.26 (95% CI: 0.87-1.81)]的死亡率高于非抑郁组[0.82 (95% CI: 0.73-0.93)]。结论抑郁性抑郁症状与较高的死亡风险密切相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Psychiatrica Scandinavica 医学-精神病学

CiteScore

11.20

自引率

3.00%

发文量

135

审稿时长

6-12 weeks

期刊介绍： Acta Psychiatrica Scandinavica acts as an international forum for the dissemination of information advancing the science and practice of psychiatry. In particular we focus on communicating frontline research to clinical psychiatrists and psychiatric researchers. Acta Psychiatrica Scandinavica has traditionally been and remains a journal focusing predominantly on clinical psychiatry, but translational psychiatry is a topic of growing importance to our readers. Therefore, the journal welcomes submission of manuscripts based on both clinical- and more translational (e.g. preclinical and epidemiological) research. When preparing manuscripts based on translational studies for submission to Acta Psychiatrica Scandinavica, the authors should place emphasis on the clinical significance of the research question and the findings. Manuscripts based solely on preclinical research (e.g. animal models) are normally not considered for publication in the Journal.