Efficacy and safety of modified fasting therapy for weight loss in 2054 hospitalized patients

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Obesity Pub Date : 2023-05-19 DOI:10.1002/oby.23756

Taoli Liu, Ziheng Ye, Jiahao Feng, Li Zhang, Hongda Chen, Xianhua Chen, Fangjie Cai, Gengpeng Zhang, Jicai Lai, Zhiyu Ye, Nan Cao, Binyan Mo, Zhiling Li, Ning Wang, Yuejia Lin, Tingying Zhang, Yu Yang, Jianguo Hu, Ling Yan, Zilong Zheng, Wei Song, Haifang Liang, Jian Qin

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引用次数: 1

Abstract

Objective

The aim of this study was to evaluate the efficacy and safety of modified fasting therapy, and a retrospective study was conducted to analyze changes in clinical indicators of hospitalized fasting patients.

Methods

A total of 2054 hospitalized fasting patients were enrolled in this observational study. All participants underwent 7 days of modified fasting therapy. The clinical efficacy biomarkers, safety indicators, and body composition were measured before and after fasting.

Results

The modified fasting therapy reduced body weight, BMI, abdominal circumference, systolic blood pressure, and diastolic blood pressure significantly. Blood glucose and indicators of body composition were improved to various extents (all p < 0.05). There was a small increase in liver function, kidney function, uric acid, electrolytes, blood count, coagulation, and uric biomarkers. Subgroup analysis results showed that cardiovascular diseases benefited from modified fasting therapy.

Conclusions

At present this study is the largest retrospective population-based study about modified fasting therapy. The results from 2054 patients showed that the modified fasting therapy lasting 7 days was efficient and safe. It led to improvements in physical health and body weight-associated indicators, as well as body composition and relevant cardiovascular risk factors.

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2054例住院患者改良禁食减肥疗法的疗效和安全性

目的评价改良禁食疗法的疗效和安全性，通过回顾性研究分析住院禁食患者临床指标的变化。方法2054例住院空腹患者纳入观察性研究。所有参与者都接受了7天的改良禁食治疗。空腹前后测定临床疗效生物标志物、安全性指标及体成分。结果改良禁食治疗可显著降低体重、BMI、腹围、收缩压和舒张压。血糖及体成分指标均有不同程度改善(p < 0.05)。肝功能、肾功能、尿酸、电解质、血细胞计数、凝血和尿酸生物标志物均有小幅增加。亚组分析结果显示心血管疾病受益于改良的禁食治疗。本研究是目前最大的基于人群的关于改良禁食疗法的回顾性研究。2054例患者的结果表明，持续7天的改良禁食治疗是有效和安全的。它改善了身体健康和体重相关指标，以及身体构成和相关心血管风险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Obesity 医学-内分泌学与代谢

CiteScore

11.70

自引率

1.40%

发文量

261

审稿时长

2-4 weeks

期刊介绍： Obesity is the official journal of The Obesity Society and is the premier source of information for increasing knowledge, fostering translational research from basic to population science, and promoting better treatment for people with obesity. Obesity publishes important peer-reviewed research and cutting-edge reviews, commentaries, and public health and medical developments.