Functional and structural brain abnormalities in substance use disorder: A multimodal meta-analysis of neuroimaging studies

IF 5.3 2区医学 Q1 PSYCHIATRY

Acta Psychiatrica Scandinavica Pub Date : 2023-02-20 DOI:10.1111/acps.13539

Hong Yan, Shu Xiao, Siying Fu, Jiaying Gong, Zhangzhang Qi, Guanmao Chen, Pan Chen, Guixian Tang, Ting Su, Zibin Yang, Ying Wang

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引用次数: 3

Abstract

Introduction

Numerous neuroimaging studies of resting-state functional imaging and voxel-based morphometry (VBM) have revealed that patients with substance use disorder (SUD) may present brain abnormalities, but their results were inconsistent. This multimodal neuroimaging meta-analysis aimed to estimate common and specific alterations in SUD patients by combining information from all available studies of spontaneous functional activity and gray matter volume (GMV).

Methods

A whole-brain meta-analysis on resting-state functional imaging and VBM studies was conducted using the Seed-based d Mapping with Permutation of Subject Images (SDM-PSI) software, followed by multimodal overlapping to comprehensively investigate function and structure of the brain in SUD.

Results

In this meta-analysis, 39 independent studies with 47 datasets related to resting-state functional brain activity (1444 SUD patients; 1446 healthy controls [HCs]) were included, as well as 77 studies with 89 datasets for GMV (3457 SUD patients; 3774 HCs). Patients with SUD showed the decreased resting-state functional brain activity in the bilateral anterior cingulate cortex/medial prefrontal cortex (ACC/mPFC). For the VBM meta-analysis, patients with SUD showed the reduced GMV in the bilateral ACC/mPFC, insula, thalamus extending to striatum, and left sensorimotor cortex.

Conclusions

This multimodal meta-analysis exhibited that SUD shows common impairment in both function and structure in the ACC/mPFC, suggesting that the deficits in functional and structural domains could be correlated together. In addition, a few regions exhibited only structural impairment in SUD, including the insula, thalamus, striatum, and sensorimotor areas.

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物质使用障碍中的功能和结构脑异常:神经影像学研究的多模态荟萃分析

大量的静息状态功能成像和基于体素的形态测量(VBM)的神经影像学研究表明，物质使用障碍(SUD)患者可能存在大脑异常，但结果不一致。这项多模式神经影像学荟分析旨在通过结合所有可用的自发功能活动和灰质体积(GMV)研究的信息来估计SUD患者的常见和特异性改变。方法采用SDM-PSI (Seed-based d Mapping with Permutation of Subject Images)软件对静息状态功能成像和VBM研究进行全脑meta分析，并进行多模态重叠，全面探讨SUD患者的脑功能和结构。结果在本荟萃分析中，39项独立研究，47个数据集与静息状态功能脑活动相关(1444例SUD患者;纳入1446名健康对照[hc]，以及77项研究和89个GMV数据集(3457名SUD患者;3774高碳钢)。SUD患者在静息状态下双侧前扣带皮层/内侧前额叶皮层(ACC/mPFC)功能脑活动降低。对于VBM meta分析，SUD患者显示双侧ACC/mPFC、脑岛、延伸至纹状体的丘脑和左侧感觉运动皮层的GMV减少。结论多模态meta分析显示，SUD在ACC/mPFC中表现出共同的功能和结构损伤，提示功能和结构域的缺陷可能是相关的。此外，SUD的一些区域仅表现出结构性损伤，包括岛、丘脑、纹状体和感觉运动区。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Psychiatrica Scandinavica 医学-精神病学

CiteScore

11.20

自引率

3.00%

发文量

135

审稿时长

6-12 weeks

期刊介绍： Acta Psychiatrica Scandinavica acts as an international forum for the dissemination of information advancing the science and practice of psychiatry. In particular we focus on communicating frontline research to clinical psychiatrists and psychiatric researchers. Acta Psychiatrica Scandinavica has traditionally been and remains a journal focusing predominantly on clinical psychiatry, but translational psychiatry is a topic of growing importance to our readers. Therefore, the journal welcomes submission of manuscripts based on both clinical- and more translational (e.g. preclinical and epidemiological) research. When preparing manuscripts based on translational studies for submission to Acta Psychiatrica Scandinavica, the authors should place emphasis on the clinical significance of the research question and the findings. Manuscripts based solely on preclinical research (e.g. animal models) are normally not considered for publication in the Journal.