Front Cover: A Study of the Activity of Adamantyl Amines against Mutant Influenza A M2 Channels Identified a Polycyclic Cage Amine Triple Blocker, Explored by Molecular Dynamics Simulations and Solid-State NMR (ChemMedChem 16/2023)

Abstract

The Front Cover illustrates the L26F variant of the M2 protein of influenza A virus which is resistant to the amantadine class of drugs. It shows the combination of two methods (MD simulations and MAS NMR) that reveal the binding of a potent inhibitor of the L26F M2 proton channel, RL208, or compound 61 in the corresponding research. The ligand RL208 is an isomer of amantadine and is described as a triple blocker of WT, L26F, V27A M2 variants. Cover design by Marianna Stampolaki and Kyriakos Georgiou; image Virus Bacterium Infection by PublicDomainPictures from Pixabay used in accordance with the Pixabay license. More information can be found in the Research Article by Μarianna Stampolaki, Anja Hoffmann, Loren B. Andreas, Michaela Schmidtke, Antonios Kolocouris et al.