Emerging tissue engineering strategies for the corneal regeneration

IF 3.1 3区生物学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Journal of Tissue Engineering and Regenerative Medicine Pub Date : 2022-05-18 DOI:10.1002/term.3309

Mahsa Fallah Tafti, Hossein Aghamollaei, Mehrdad Moosazadeh Moghaddam, Khosrow Jadidi, Jorge L. Alio, Shahab Faghihi

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引用次数: 3

Abstract

Cornea as the outermost layer of the eye is at risk of various genetic and environmental diseases that can damage the cornea and impair vision. Corneal transplantation is among the most applicable surgical procedures for repairing the defected tissue. However, the scarcity of healthy tissue donations as well as transplantation failure has remained as the biggest challenges in confront of corneal grafting. Therefore, alternative approaches based on stem-cell transplantation and classic regenerative medicine have been developed for corneal regeneration. In this review, the application and limitation of the recently-used advanced approaches for regeneration of cornea are discussed. Additionally, other emerging powerful techniques such as 5D printing as a new branch of scaffold-based technologies for construction of tissues other than the cornea are highlighted and suggested as alternatives for corneal reconstruction. The introduced novel techniques may have great potential for clinical applications in corneal repair including disease modeling, 3D pattern scheming, and personalized medicine.

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角膜再生的新兴组织工程策略

角膜作为眼睛的最外层，存在着各种遗传和环境疾病的风险，这些疾病会损害角膜，损害视力。角膜移植是修复缺损组织最适用的外科手术方法之一。然而，健康组织的稀缺和移植失败仍然是角膜移植面临的最大挑战。因此，基于干细胞移植和经典再生医学的替代方法已被开发用于角膜再生。本文就近年来先进角膜再生方法的应用及局限性作一综述。此外，其他新兴的强大技术，如5D打印作为基于支架的组织构建技术的一个新分支，被强调并建议作为角膜重建的替代方案。所介绍的新技术可能在角膜修复的疾病建模、三维模式规划和个性化医疗方面具有很大的临床应用潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Tissue Engineering and Regenerative Medicine 生物-工程：生物医学

CiteScore

7.50

自引率

3.00%

发文量

审稿时长

4-8 weeks

期刊介绍： Journal of Tissue Engineering and Regenerative Medicine publishes rapidly and rigorously peer-reviewed research papers, reviews, clinical case reports, perspectives, and short communications on topics relevant to the development of therapeutic approaches which combine stem or progenitor cells, biomaterials and scaffolds, growth factors and other bioactive agents, and their respective constructs. All papers should deal with research that has a direct or potential impact on the development of novel clinical approaches for the regeneration or repair of tissues and organs. The journal is multidisciplinary, covering the combination of the principles of life sciences and engineering in efforts to advance medicine and clinical strategies. The journal focuses on the use of cells, materials, and biochemical/mechanical factors in the development of biological functional substitutes that restore, maintain, or improve tissue or organ function. The journal publishes research on any tissue or organ and covers all key aspects of the field, including the development of new biomaterials and processing of scaffolds; the use of different types of cells (mainly stem and progenitor cells) and their culture in specific bioreactors; studies in relevant animal models; and clinical trials in human patients performed under strict regulatory and ethical frameworks. Manuscripts describing the use of advanced methods for the characterization of engineered tissues are also of special interest to the journal readership.