Effect of normal rat serum injected into the uterus on fetal survival in the rat

Journal of experimental animal science Pub Date : 2003-03-01 DOI:10.1016/S0939-8600(03)80010-X

Reuvit Halperin , Eran Hadas , Nili Shinnar , Ian Bukovsky , David Schneider

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引用次数: 1

Abstract

We intended to use the rat model to study the effect of autoantibodies on implantation and fetal viability. However, we have since found an effect of normal rat serum on fetal resorption rate and fetal viability. The objective of this study was to determine the consistency of this effect. Wistar strain albino rats were used for injection of 150 μl normal rat serum into the lumen of uterine horn on days L₂–L₆. The other uterine horn, used as a control, was injected with 150 μl normal saline. Percent implantation, fetal resorption rate and fetal viability were determined following the intrauterine injection of normal rat serum as compared with normal saline. A significant increase in fetal resorption rate was observed following the injection of rat serum on days L₄ and L₅ (P = 0.003 and P = 0.001, respectively). A significant decrease in fetal viability was demonstrated following the injection of rat serum on day L₅ (P = 0.01). The rat can provide a suitable animal model for further studies.

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子宫内注射正常大鼠血清对大鼠胎儿存活的影响

我们打算用大鼠模型研究自身抗体对着床和胎儿生存能力的影响。然而，我们已经发现正常大鼠血清对胎儿吸收率和胎儿生存能力的影响。本研究的目的是确定这种效果的一致性。取Wistar系白化大鼠于l2 ~ l6天子宫角腔内注射正常大鼠血清150 μl。另一侧子宫角作为对照，注射生理盐水150 μl。测定子宫内注射正常大鼠血清和生理盐水后的着床率、胎儿吸收率和胎儿生存能力。注射大鼠血清后第4、5天胎儿吸收率显著升高(P = 0.003、P = 0.001)。在L5天注射大鼠血清后，胎儿存活率显著降低(P = 0.01)。该大鼠可为进一步研究提供合适的动物模型。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Journal of experimental animal science

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