Effects of fibrin on the integration hydroxyapatite coating implants: experimental study in a rabbit model

M. Morales , R. Navarro , M. Almenara , J.M. Medina , C. Melian , C. Gutierrez
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引用次数: 6

Abstract

The purpose of this study was to investigate the effects of the addition of fibrin (SAF) to titanium alloy implants coated with hydroxyapatite (HAP) on osteogenesis in rabbits. A titanium (Ti) alloy implant was inserted into the femoral neck of twenty-four adult rabbits. Six rabbits were included on each of the following groups: Ti control, HAP-coated Ti module, HAP-coated Ti module with added fibrin glue and Ti module also with added fibrin glue. After seven weeks, bone growth was examined radiographically and by histo-morphometry. The SAF/HAP mixture did caused to a significant increase in bone growth compared to the other groups. The addition of fibrin did not result in an increase in new-bone growth and increase the formation of fibrous tissue in contact with the implant. We concluded that SAF did not demonstrate osteoinductive properties.

纤维蛋白对羟基磷灰石涂层植入物影响的兔模型实验研究
本研究旨在探讨羟基磷灰石(HAP)包覆钛合金种植体中添加纤维蛋白(SAF)对兔骨形成的影响。将钛(Ti)合金植入24只成年兔的股骨颈。每组6只兔:Ti对照组、hap包被Ti模组、添加纤维蛋白胶的hap包被Ti模组和添加纤维蛋白胶的Ti模组。7周后,通过x线摄影和组织形态学检查骨生长情况。与其他组相比,SAF/HAP混合物确实导致骨生长显著增加。添加纤维蛋白并没有导致新骨生长的增加,也没有增加与植入物接触的纤维组织的形成。我们得出结论,SAF不具有骨诱导特性。
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