Effects of a topical silver sulfadiazine polyurethane dressing (Mikacure) on wound healing in experimentally infected wounds in the pig. A pilot study

Abstract

An infected pig (sus scrofa domesticus) wound model was used to compare treatment with Mikacure, a topical silver sulfadiazine (SSD)-impregnated polyurethane dressing (SSD-PUR) with commercially available hydrocolloid wound dressing and dressing with wet gauze. Mikacure led to earlier wound granulation and better wound scores compared with hydrocolloid or wet gauze wound treatment. The differences were most pronounced on day 3 after surgery. The histological investigation of biopsy and necropsy samples revealed minor degrees of infection and inflammation but an earlier and increased epithelialisation compared with hydrocolloid dressing and wet gauze.