Genetic analysis of hypertension in the Dahl salt-sensitive rat

J.P. Rapp
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Abstract

Quantitative trait loci (QTL) for blood pressure were sought using crosses of Dahl salt sensitive (S) rats and various normotensive strains. Multiple QTL were detected by linkage analysis and these were confirmed by construction of congenic strains for the QTL on chromosomes 1, 2, 3, 5, 7, 9, 10 and 13.

达尔盐敏感大鼠高血压的遗传分析
利用达尔盐敏感(S)大鼠与各种正常血压品系的杂交,寻找血压的数量性状位点(QTL)。通过连锁分析检测到多个QTL,并对1、2、3、5、7、9、10和13号染色体上的QTL进行了同源菌株的构建。
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