Effect of omega-3 fatty acid supplementation on telomere length and telomerase activity: A systematic review of clinical trials

IF 3

Prostaglandins, leukotrienes, and essential fatty acids Pub Date : 2022-06-01 DOI:10.1016/j.plefa.2022.102451

Alessandra da Silva , Brenda Kelly Souza Silveira , Helen Hermana Miranda Hermsdorff , Walmir da Silva , Josefina Bressan

{"title":"Effect of omega-3 fatty acid supplementation on telomere length and telomerase activity: A systematic review of clinical trials","authors":"Alessandra da Silva , Brenda Kelly Souza Silveira , Helen Hermana Miranda Hermsdorff , Walmir da Silva , Josefina Bressan","doi":"10.1016/j.plefa.2022.102451","DOIUrl":null,"url":null,"abstract":"<div><p>Evidence suggests antioxidant and anti-inflammatory properties of omega-3 polyunsaturated fatty acids (n-3 PUFA). However, the effect of supplementation of this fatty acid profile on the telomere length and the telomerase enzyme activity was not revised yet. The PubMed and Embase® databases were used to search for clinical trials. A total of six clinical trials were revised. Omega-3 PUFA supplementation did not statistically affect telomere length in three out of three studies but affected telomerase activity in two out of four studies. The supplementation increased telomerase enzyme activity in subjects with first-episode schizophrenia. Besides, it decreased telomerase enzyme activity without modulating the effects of Pro12Ala polymorphism on the PPARγ gene in type 2 diabetes subjects. The methodological differences between the studies and the limited number of studies on the theme suggest that further studies are needed to elucidate the effects of n-3 PUFA supplementation on telomere length and telomerase enzyme activity in humans.</p></div>","PeriodicalId":94179,"journal":{"name":"Prostaglandins, leukotrienes, and essential fatty acids","volume":null,"pages":null},"PeriodicalIF":3.0000,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Prostaglandins, leukotrienes, and essential fatty acids","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0952327822000631","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 2

Abstract

Evidence suggests antioxidant and anti-inflammatory properties of omega-3 polyunsaturated fatty acids (n-3 PUFA). However, the effect of supplementation of this fatty acid profile on the telomere length and the telomerase enzyme activity was not revised yet. The PubMed and Embase® databases were used to search for clinical trials. A total of six clinical trials were revised. Omega-3 PUFA supplementation did not statistically affect telomere length in three out of three studies but affected telomerase activity in two out of four studies. The supplementation increased telomerase enzyme activity in subjects with first-episode schizophrenia. Besides, it decreased telomerase enzyme activity without modulating the effects of Pro12Ala polymorphism on the PPARγ gene in type 2 diabetes subjects. The methodological differences between the studies and the limited number of studies on the theme suggest that further studies are needed to elucidate the effects of n-3 PUFA supplementation on telomere length and telomerase enzyme activity in humans.

查看原文本刊更多论文

补充omega-3脂肪酸对端粒长度和端粒酶活性的影响:临床试验的系统回顾

有证据表明omega-3多不饱和脂肪酸具有抗氧化和抗炎特性。然而，补充这种脂肪酸谱对端粒长度和端粒酶活性的影响尚未得到修正。使用PubMed和Embase®数据库搜索临床试验。共修改了6项临床试验。在3 / 3的研究中，补充Omega-3 PUFA没有影响端粒长度，但在4 / 2的研究中影响端粒酶活性。这种补充剂增加了首发精神分裂症患者的端粒酶活性。此外，它降低端粒酶活性，但不调节Pro12Ala多态性对2型糖尿病患者PPARγ基因的影响。这些研究之间的方法差异和有限数量的研究表明，需要进一步的研究来阐明n-3 PUFA补充对人类端粒长度和端粒酶活性的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊