Comparing the Digoxin Test With the Architect®i1000 sr System With Respect to the AxSYM® System

Farmacia Hospitalaria (English Edition) Pub Date : 2011-09-01 DOI:10.1016/j.farmae.2011.02.001

E. Albert Vicent, R. Ferriols Lisart, M.A. Roch Ventura, M. Alós Almiñana

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Abstract

Objective

To assess the technique employed by the autoanalyser Architect^® i1000 sr to determine digoxin in serum samples, compared with the assay developed for AsSYM^® using microparticle enzyme immunoassay (Digoxin II).

Method

A prospective analysis of the samples from 100 requests to monitor patients being treated with digoxin. The samples were processed in AxSYM^® and Architect^®. The techniques were assessed using the linear regression coefficient, determination coefficient, mean absolute error, mean squared prediction error and the Bland-Altman method.

Results

The serum levels showed a correlation coefficient of 0.93. There was nearly a 40% difference for the concentrations between 0.8 and 2 ng/ml and nearly 20% in the rest of the samples analysed.

Conclusions

The Architect^® system is precise; however, from a clinical monitoring point of view, it is unacceptably inaccurate when compared with the AxSYM^®.

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地高辛测试与Architect®i1000 sr系统与AxSYM®系统的比较

目的评价Architect®i1000 sr自动分析仪用于测定血清样本中地高辛的技术，并与AsSYM®使用微粒酶免疫分析法(地高辛II)开发的方法进行比较。方法对100例使用地高辛治疗的患者的监测样本进行前瞻性分析。样品在AxSYM®和Architect®中进行处理。采用线性回归系数、决定系数、平均绝对误差、均方预测误差和Bland-Altman方法对技术进行评价。结果血药浓度相关系数为0.93。在0.8和2纳克/毫升之间的浓度有近40%的差异，在分析的其他样品中有近20%的差异。Architect®系统是精确的;然而，从临床监测的角度来看，与AxSYM®相比，它是不可接受的不准确。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Farmacia Hospitalaria (English Edition)

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