Mechanism of Action of Temporary Peripheral Nerve Stimulation.

IF 3.2 2区医学 Q2 CLINICAL NEUROLOGY

Current Pain and Headache Reports Pub Date : 2024-12-01 Epub Date: 2023-10-27 DOI:10.1007/s11916-023-01184-5

Alaa Abd-Elsayed, Sumedha Attanti, Meredith Anderson, Tyler Dunn, Jillian Maloney, Natalie Strand

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引用次数: 0

Abstract

Purpose of review: Peripheral nerve stimulation (PNS) refers to the technique of utilizing electrical stimulation of peripheral nerves to inhibit the transmission of pain signals. PNS is used to treat chronic intractable pain and post-surgical or post-traumatic pain alongside a variety of other pain conditions, including headaches, facial pain, pelvic and urogenital pain, chest wall pain, residual limb or phantom limb pain, and back pain.

Recent findings: More recently, PNS has been used temporarily for periods of time less than 60 days to treat acute post-surgical pain. Peripheral nerve stimulation is believed to be effective due to its effects on both central and peripheral pathways. Centrally, it is proposed that the electrical pulses of PNS inhibit alpha-delta and C fibers, which decreases pain signaling in the higher centers of the central nervous system. Peripherally, gate theory is applied as it is theorized that PNS downregulates inflammatory mediators, endorphins, and neurotransmitters associated with pain signaling to decrease the transmission of efferent nociception and reduce pain sensations.

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临时性周围神经刺激的作用机制。

综述目的：外周神经刺激（PNS）是指利用电刺激外周神经来抑制疼痛信号传输的技术。PNS用于治疗慢性顽固性疼痛、术后或创伤后疼痛以及各种其他疼痛状况，包括头痛、面部疼痛、骨盆和泌尿生殖道疼痛、胸壁疼痛、残肢或幻肢疼痛以及背痛。最近的发现：最近，PNS被临时使用不到60天的时间来治疗术后急性疼痛。外周神经刺激被认为是有效的，因为它对中枢和外周通路都有影响。在中枢，有人提出PNS的电脉冲抑制α-δ和C纤维，这降低了中枢神经系统高级中枢的疼痛信号。在外围，门理论被应用，因为它的理论是PNS下调炎症介质、内啡肽和与疼痛信号相关的神经递质，以减少传出伤害感受的传递并减少疼痛感。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Pain and Headache Reports CLINICAL NEUROLOGY-

CiteScore

6.10

自引率

2.70%

发文量

审稿时长

6-12 weeks

期刊介绍： This journal aims to review the most important, recently published clinical findings regarding the diagnosis, treatment, and management of pain and headache. By providing clear, insightful, balanced contributions by international experts, the journal intends to serve all those involved in the care and prevention of pain and headache. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as anesthetic techniques in pain management, cluster headache, neuropathic pain, and migraine. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.