Ceria-vesicle nanohybrid therapeutic for modulation of innate and adaptive immunity in a collagen-induced arthritis model

IF 38.1 1区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Nature nanotechnology Pub Date : 2023-10-26 DOI:10.1038/s41565-023-01523-y

Sagang Koo, Hee Su Sohn, Tae Hee Kim, Siyeon Yang, Se Youn Jang, Seongryeol Ye, Boomin Choi, Soo Hyeon Kim, Kyoung Sun Park, Hyun Mu Shin, Ok Kyu Park, Cheesue Kim, Mikyung Kang, Min Soh, Jin Yoo, Dokyoon Kim, Nohyun Lee, Byung-Soo Kim, Youngmee Jung, Taeghwan Hyeon

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Abstract

Commencing with the breakdown of immune tolerance, multiple pathogenic factors, including synovial inflammation and harmful cytokines, are conjointly involved in the progression of rheumatoid arthritis. Intervening to mitigate some of these factors can bring a short-term therapeutic effect, but other unresolved factors will continue to aggravate the disease. Here we developed a ceria nanoparticle-immobilized mesenchymal stem cell nanovesicle hybrid system to address multiple factors in rheumatoid arthritis. Each component of this nanohybrid works individually and also synergistically, resulting in comprehensive treatment. Alleviation of inflammation and modulation of the tissue environment into an immunotolerant-favourable state are combined to recover the immune system by bridging innate and adaptive immunity. The therapy is shown to successfully treat and prevent rheumatoid arthritis by relieving the main symptoms and also by restoring the immune system through the induction of regulatory T cells in a mouse model of collagen-induced arthritis. Rheumatoid arthritis involves both inflammation and immune dysfunction, yet most therapies only target one aspect. Here, the authors report on ceria nanoparticle vesicle hybrids producing anti-inflammatory action and immunomodulation to relieve symptoms and restore normal function.

Abstract Image

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Ceria囊泡纳米杂交疗法在胶原诱导的关节炎模型中调节先天免疫和适应性免疫。

从免疫耐受的崩溃开始，包括滑膜炎症和有害细胞因子在内的多种致病因素共同参与了类风湿性关节炎的进展。干预以减轻其中一些因素可以带来短期的治疗效果，但其他未解决的因素将继续加重疾病。在这里，我们开发了一种二氧化铈纳米颗粒固定的间充质干细胞纳米囊泡混合系统，以解决类风湿性关节炎的多种因素。这种纳米杂化物的每个组成部分都单独工作，也协同工作，从而产生综合处理。炎症的缓解和组织环境调节到免疫耐受的有利状态相结合，通过桥接先天免疫和适应性免疫来恢复免疫系统。该疗法通过缓解主要症状以及通过在胶原诱导的关节炎小鼠模型中诱导调节性T细胞来恢复免疫系统，被证明可以成功地治疗和预防类风湿性关节炎。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature nanotechnology 工程技术-材料科学：综合

CiteScore

59.70

自引率

0.80%

发文量

196

审稿时长

4-8 weeks

期刊介绍： Nature Nanotechnology is a prestigious journal that publishes high-quality papers in various areas of nanoscience and nanotechnology. The journal focuses on the design, characterization, and production of structures, devices, and systems that manipulate and control materials at atomic, molecular, and macromolecular scales. It encompasses both bottom-up and top-down approaches, as well as their combinations. Furthermore, Nature Nanotechnology fosters the exchange of ideas among researchers from diverse disciplines such as chemistry, physics, material science, biomedical research, engineering, and more. It promotes collaboration at the forefront of this multidisciplinary field. The journal covers a wide range of topics, from fundamental research in physics, chemistry, and biology, including computational work and simulations, to the development of innovative devices and technologies for various industrial sectors such as information technology, medicine, manufacturing, high-performance materials, energy, and environmental technologies. It includes coverage of organic, inorganic, and hybrid materials.