Effects of rhBMP-2 with various carriers on maxillofacial bone regeneration through computed tomography evaluation.

IF 2 Q2 DENTISTRY, ORAL SURGERY & MEDICINE
Ja In Seo, Ji Hye Lim, Woo Min Jo, Jeong Keun Lee, Seung Il Song
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引用次数: 0

Abstract

Background: rhBMP-2 is regarded as the most potent osteoinductive growth factor, and it has been used in the oral cavity with different carriers. The purpose of this study is to evaluate the bone-regenerative effect of rhBMP-2 delivered with different carrier systems through three-dimensional cone beam computed tomography analysis.

Method: A total of 112 patients underwent oral surgery with rhBMP-2 application (Group 1, n = 53) or without rhBMP-2 application (Group 2, n = 59). Group 1 was divided into 3 groups according to carriers, rhBMP-2 with allograft (Group 1-1, n = 34), rhBMP-2 with xenograft (Group 1-2, n = 5), and rhBMP-2 with absorbable collagen sponge (Group 1-3, n = 14). Cone beam computed tomography scans were taken before surgery (T0) 6 months after surgery (T1). The volume of defects was measured through the three-dimensional image analysis tool.

Results: The average bone regeneration rate of Group 1 was significantly greater than that of Group 2. Within Group 1, the group that used allograft as a carrier (Group 1-1) showed significantly higher bone regeneration rates than the group that used absorbable collagen sponge as a carrier (Group 1-3).

Conclusion: The use of rhBMP-2 after oral surgery results in a superior bone regeneration rate compared to not using rhBMP-2, and its efficacy depends on the carriers it is used with. Allograft affects bone regeneration more than absorbable collagen sponge when it is carried with rhBMP-2. Therefore, the appropriate use of rhBMP-2 with suitable bone grafting materials is useful for promoting postoperative bone regeneration in oral surgery.

通过计算机断层扫描评估rhBMP-2与各种载体对颌面骨再生的影响。
背景:rhBMP-2被认为是最有效的骨诱导生长因子,它已被不同载体应用于口腔。本研究的目的是通过三维锥束计算机断层扫描分析,评估不同载体系统递送的rhBMP-2的骨再生效果。方法:共有112例患者接受了应用rhBMP-2的口腔手术(第1组 = 53)或不施用rhBMP-2(组2 = 59)。第1组按载体分为3组,rhBMP-2与同种异体骨移植(1-1组 = 34),rhBMP-2与异种移植物(组1-2,n = 5) ,和rhBMP-2与可吸收胶原海绵(1-3组,n = 14) 。术前(T0)、术后6个月(T1)进行锥束计算机断层扫描。通过三维图像分析工具测量缺陷的体积。结果:第1组的平均骨再生率明显高于第2组。在第1组中,使用同种异体移植物作为载体的组(1-1组)的骨再生率明显高于使用可吸收胶原海绵作为载体的对照组(1-3组)。当与rhBMP-2一起携带时,同种异体移植物比可吸收的胶原海绵更能影响骨再生。因此,在口腔外科手术中,适当使用rhBMP-2和合适的骨移植材料有助于促进术后骨再生。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Maxillofacial Plastic and Reconstructive Surgery
Maxillofacial Plastic and Reconstructive Surgery DENTISTRY, ORAL SURGERY & MEDICINE-
CiteScore
4.30
自引率
13.00%
发文量
37
审稿时长
13 weeks
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