Salt-Taste Polymorphism TRPV1-rs8065080 Is Associated with Increased Likelihood of Depression in an Elderly Cohort.

IF 2 4区 医学 Q3 GENETICS & HEREDITY
Lifestyle Genomics Pub Date : 2023-01-01 Epub Date: 2023-10-26 DOI:10.1159/000534521
Celeste Ferraris, Christopher J Scarlett, Martin Veysey, Mark Lucock, Tamara Bucher, Emma L Beckett
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引用次数: 0

Abstract

Introduction: Despite the prevalence of depression and anxiety worldwide, their aetiologies remain unclear, and they can be difficult to diagnose and treat. Changes in salt-taste perception have been found in both conditions. Single-nucleotide polymorphisms (SNPs) in the salt-taste-related gene, TRPV1, have been associated with alterations to salt-taste perception, preference, and sodium consumption. Diet quality is a known modifier of depression and anxiety and recently, sodium intake has been studied in mental health. However, the relationships between salt-taste genetics, depression, anxiety, and these dietary factors are yet to be elucidated.

Methods: Data from the well-characterized cross-sectional Retirement Health and Lifestyle Study (n = 536, ≥65 y) were used to explore the relationships between the salt-taste SNP TRPV1-rs8065080, levels of depression and anxiety (Hospital Anxiety and Depression Scale, HADS), estimated sodium intake, and diet quality in this secondary analysis. Standard least-squares regression and nominal logistic regression modelling were used to compare continuous and categorical variables, respectively, with analyses stratified by sex.

Results: Presence of the TRPV1-rs8065080 variant allele (C) was found to increase the likelihood of having depression (HADS) in the total population and in males. The associations remained significant after adjusting for sodium intake, three diet quality indices, and demographic variables, suggesting that TRPV1-rs8065080 genotype is driving the association with depression.

Discussion/conclusion: Future studies should explore extra-oral functions of the SNP and salt-taste receptors in the brain and the roles of neurotransmitters common to both depression and salt taste to improve the management of this increasingly prevalent and difficult-to-treat condition.

在一个老年队列中,盐味多态性TRPV1-rs8065080与抑郁症的可能性增加有关。
引言:尽管抑郁症和焦虑症在全球范围内普遍存在,但其病因尚不清楚,而且很难诊断和治疗。在这两种情况下都发现了盐味觉的变化。盐味相关基因TRPV1中的单核苷酸多态性(SNPs)与盐味感知、偏好和钠消耗的改变有关。饮食质量是抑郁症和焦虑症的一个已知调节因素,最近,钠的摄入在心理健康方面进行了研究。然而,盐味遗传、抑郁、焦虑和这些饮食因素之间的关系尚待阐明。方法:在这项二次分析中,使用来自具有良好特征的横断面退休健康和生活方式研究(n=536,≥65y)的数据来探讨盐味SNP TRPV1-rs8065080、抑郁和焦虑水平(医院焦虑和抑郁量表,HADS)、估计钠摄入量和饮食质量之间的关系。标准最小二乘回归和标称逻辑回归模型分别用于比较连续变量和分类变量,并按性别进行分层分析。结果:发现TRPV1-rs8065080变异等位基因(C)的存在会增加总人群和男性患抑郁症(HADS)的可能性。在调整了钠摄入量、三项饮食质量指数和人口统计学变量后,这些相关性仍然显著,这表明TRPV1-rs8065080基因型是抑郁症的驱动因素。讨论/结论:未来的研究应该探索大脑中SNP和咸味受体的口腔外功能,以及抑郁症和咸味常见的神经递质的作用,以改善对这种日益普遍和难以治疗的疾病的管理。
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来源期刊
Lifestyle Genomics
Lifestyle Genomics Agricultural and Biological Sciences-Food Science
CiteScore
4.00
自引率
7.70%
发文量
11
审稿时长
28 weeks
期刊介绍: Lifestyle Genomics aims to provide a forum for highlighting new advances in the broad area of lifestyle-gene interactions and their influence on health and disease. The journal welcomes novel contributions that investigate how genetics may influence a person’s response to lifestyle factors, such as diet and nutrition, natural health products, physical activity, and sleep, amongst others. Additionally, contributions examining how lifestyle factors influence the expression/abundance of genes, proteins and metabolites in cell and animal models as well as in humans are also of interest. The journal will publish high-quality original research papers, brief research communications, reviews outlining timely advances in the field, and brief research methods pertaining to lifestyle genomics. It will also include a unique section under the heading “Market Place” presenting articles of companies active in the area of lifestyle genomics. Research articles will undergo rigorous scientific as well as statistical/bioinformatic review to ensure excellence.
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