Systems biology approaches to study the molecular effects of caloric restriction and polyphenols on aging processes.

IF 3.3 3区 医学 Q2 GENETICS & HEREDITY
Genes and Nutrition Pub Date : 2015-11-01 Epub Date: 2015-11-25 DOI:10.1007/s12263-015-0508-9
Sébastien Lacroix, Mario Lauria, Marie-Pier Scott-Boyer, Luca Marchetti, Corrado Priami, Laura Caberlotto
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引用次数: 0

Abstract

Worldwide population is aging, and a large part of the growing burden associated with age-related conditions can be prevented or delayed by promoting healthy lifestyle and normalizing metabolic risk factors. However, a better understanding of the pleiotropic effects of available nutritional interventions and their influence on the multiple processes affected by aging is needed to select and implement the most promising actions. New methods of analysis are required to tackle the complexity of the interplay between nutritional interventions and aging, and to make sense of a growing amount of -omics data being produced for this purpose. In this paper, we review how various systems biology-inspired methods of analysis can be applied to the study of the molecular basis of nutritional interventions promoting healthy aging, notably caloric restriction and polyphenol supplementation. We specifically focus on the role that different versions of network analysis, molecular signature identification and multi-omics data integration are playing in elucidating the complex mechanisms underlying nutrition, and provide some examples on how to extend the application of these methods using available microarray data.

采用系统生物学方法研究热量限制和多酚对衰老过程的分子影响。
全球人口正在步入老龄化,而与老龄相关的疾病所造成的日益沉重的负担,很大一部分是可以通过促进健康的生活方式和使代谢风险因素正常化来预防或延缓的。然而,需要更好地了解现有营养干预措施的多效应及其对受老龄化影响的多种过程的影响,以选择和实施最有前景的行动。我们需要新的分析方法来解决营养干预与衰老之间复杂的相互作用,并对为此目的而产生的越来越多的组学数据进行分析。在本文中,我们回顾了如何将各种受系统生物学启发的分析方法应用于研究促进健康老龄化的营养干预措施(特别是热量限制和多酚补充)的分子基础。我们特别关注不同版本的网络分析、分子特征识别和多组学数据整合在阐明营养的复杂机制方面所发挥的作用,并提供了一些实例,说明如何利用现有的微阵列数据扩展这些方法的应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Genes and Nutrition
Genes and Nutrition 生物-遗传学
CiteScore
6.60
自引率
0.00%
发文量
14
审稿时长
6-12 weeks
期刊介绍: This journal examines the relationship between genetics and nutrition, with the ultimate goal of improving human health. It publishes original research articles and review articles on preclinical research data coming largely from animal, cell culture and other experimental models as well as critical evaluations of human experimental data to help deliver products with medically proven use.
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