Colorimetric sensing strategy for detection of cysteine, phenol cysteine, and phenol based on synergistic doping of multiple heteroatoms into sponge-like Fe/NPC nanozymes

IF 3.8 2区化学 Q1 BIOCHEMICAL RESEARCH METHODS

Analytical and Bioanalytical Chemistry Pub Date : 2022-04-25 DOI:10.1007/s00216-022-04074-8

Yuting Xue, Haotian Zhong, Bin Liu, Ruixue Zhao, Jun Ma, Zhengbo Chen, Kai Li, Xia Zuo

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引用次数: 1

Abstract

Nanozymes have both the high catalytic activity of natural enzymes and the stability and economy of mimetic enzymes. Research on nanozymes is rapidly emerging, and the continuous development of highly catalytic active nanozymes is of far-reaching significance. This work reports heteroatomic nitrogen (N) and phosphorus (P) double-doped mesoporous carbon structures and metallic Fe coordination generated sponge-like nanozymes (Fe/NPCs) with good peroxidase activity. On this basis, we constructed a highly sensitive colorimetric sensor with cysteine and phenol as simulated analytes using Fe/NPCs nanozymes, and the response limits reached 53.6 nM and 5.4 nM, respectively. Besides, the method has high accuracy in the detection of cysteine and phenol at low concentrations in serum and tap water, which lays a foundation for application in the fields of environmental protection and biosensors.

Graphical abstract

查看原文本刊更多论文

基于多杂原子协同掺杂海绵状Fe/NPC纳米酶的半胱氨酸、半胱氨酸和苯酚的比色传感检测策略

纳米酶既具有天然酶的高催化活性，又具有模拟酶的稳定性和经济性。纳米酶的研究正在迅速兴起，不断开发具有高催化活性的纳米酶具有深远的意义。本文报道了杂原子氮(N)和磷(P)双掺杂介孔碳结构和金属铁配位产生具有良好过氧化物酶活性的海绵状纳米酶(Fe/NPCs)。在此基础上，利用Fe/NPCs纳米酶，以半胱氨酸和苯酚为模拟分析物，构建了高灵敏度的比色传感器，响应限分别达到53.6 nM和5.4 nM。此外，该方法对血清和自来水中低浓度半胱氨酸和苯酚的检测具有较高的准确性，为在环保和生物传感器领域的应用奠定了基础。图形抽象

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Analytical and Bioanalytical Chemistry 化学-分析化学

CiteScore

8.00

自引率

4.70%

发文量

638

审稿时长

2.1 months

期刊介绍： Analytical and Bioanalytical Chemistry’s mission is the rapid publication of excellent and high-impact research articles on fundamental and applied topics of analytical and bioanalytical measurement science. Its scope is broad, and ranges from novel measurement platforms and their characterization to multidisciplinary approaches that effectively address important scientific problems. The Editors encourage submissions presenting innovative analytical research in concept, instrumentation, methods, and/or applications, including: mass spectrometry, spectroscopy, and electroanalysis; advanced separations; analytical strategies in “-omics” and imaging, bioanalysis, and sampling; miniaturized devices, medical diagnostics, sensors; analytical characterization of nano- and biomaterials; chemometrics and advanced data analysis.