The role of neutrophils in host defense against invasive fungal infections.

IF 3.1 Q2 MICROBIOLOGY

Current Clinical Microbiology Reports Pub Date : 2018-09-01 Epub Date: 2018-06-22 DOI:10.1007/s40588-018-0098-6

Jigar V Desai, Michail S Lionakis

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引用次数: 0

Abstract

Purpose of review: Invasive fungal infections caused by the commensal yeast Candida and the ubiquitous, inhaled mold Aspergillus have emerged as major causes of morbidity and mortality in critically ill and immunosuppressed patient populations. Here, we review how neutrophils contribute to effective immunity against these infections.

Recent findings: Studies in mouse models of invasive candidiasis and aspergillosis, and observations in hematological patients with chemotherapy-induced neutropenia and in patients with primary immunodeficiency disorders that manifest with these infections have highlighted the critical role of neutrophils and have identified key immune factors that promote neutrophil-mediated effective host defense against invasive fungal disease.

Summary: Neutrophils are crucial in host protection against invasive candidiasis and aspergillosis. Recent advances in our understanding of the molecular cues that mediate protective neutrophil recruitment and effector function against these infections hold promise for developing immune-based strategies to improve the outcomes of affected patients.

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中性粒细胞在宿主防御侵袭性真菌感染中的作用。

综述目的：由共生酵母菌念珠菌和无所不在的吸入性霉菌曲霉引起的侵袭性真菌感染已成为危重症和免疫抑制患者发病和死亡的主要原因。在这里，我们回顾中性粒细胞如何有助于有效免疫这些感染。最近的研究发现：侵袭性念珠菌病和曲霉病小鼠模型的研究，以及对化疗诱导的中性粒细胞减少的血液病患者和以这些感染为表现的原发性免疫缺陷疾病患者的观察，都强调了中性粒细胞的关键作用，并确定了促进中性粒细胞介导的有效宿主防御侵袭性真菌疾病的关键免疫因子。摘要：中性粒细胞在宿主抵御侵袭性念珠菌病和曲霉病方面起着至关重要的作用。我们对介导保护性中性粒细胞募集的分子线索和对这些感染的效应功能的理解的最新进展，为开发基于免疫的策略来改善受影响患者的预后带来了希望。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Clinical Microbiology Reports MICROBIOLOGY-

CiteScore

7.50

自引率

1.90%

发文量

期刊介绍： Current Clinical Microbiology Reports commissions expert reviews from leading scientists at the forefront of research in microbiology. The journal covers this broad field by dividing it into four key main areas of study: virology, bacteriology, parasitology, and mycology. Within each of the four sections, experts from around the world address important aspects of clinical microbiology such as immunology, diagnostics, therapeutics, antibiotics and antibiotic resistance, and vaccines. Some of the world’s foremost authorities in the field of microbiology serve as section editors and editorial board members. Section editors select topics for which leading researchers are invited to contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, which are highlighted in annotated reference lists. These timely reviews of the literature examine the latest scientific discoveries and controversies as they emerge and are indispensable to both researchers and clinicians. The editorial board, composed of more than 20 internationally diverse members, reviews the annual table of contents, ensures that topics address all aspects of emerging research, and where applicable suggests topics of critical importance to various countries/regions.