Amphiphilic Copolymers of Different Structure Based on Poly(ethylene glycol): Synthesis, Physico-Chemical Properties, and Cytotoxicity

IF 1.6 4区化学 Q4 POLYMER SCIENCE

Polymer Science, Series C Pub Date : 2022-08-31 DOI:10.1134/S1811238222700126

M. Yu. Zaremski, N. S. Melik-Nubarov, I. D. Grozdova, E. E. Aliev, S. A. Rumyantsev

引用次数: 0

Abstract

New procedures for the preparation of grafted and branched amphiphilic copolymers based on poly(ethylene glycol) have been suggested. Radical polymerization with TEMPO and sulfuric acid has afforded controlled synthesis of grafted copolymers of methyl methacrylate with poly(ethylene glycol) methacrylate. Radical copolymerization of allyl acetate with poly(ethylene glycol) acrylate in the presence of divinylbenzene has given branched copolymers. It has been shown that these copolymers can form micelles in aqueous medium; cytotoxicity of the copolymers and the ability to suppress the resistance of human cancer cells NCI/ADR-RES have been investigated.

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基于聚乙二醇的不同结构两亲共聚物:合成、物理化学性质和细胞毒性

提出了以聚乙二醇为基的接枝和支链两亲共聚物的制备新工艺。用TEMPO和硫酸进行自由基聚合，合成了甲基丙烯酸甲酯与聚甲基丙烯酸乙二醇接枝共聚物。在二乙烯基苯的存在下，醋酸烯丙酯与聚乙二醇丙烯酸酯自由基共聚得到支链共聚物。研究表明，这些共聚物能在水介质中形成胶束;研究了共聚物的细胞毒性和抑制人类癌细胞NCI/ADR-RES耐药性的能力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Polymer Science, Series C 工程技术-高分子科学

CiteScore

3.00

自引率

4.50%

发文量

审稿时长

>12 weeks

期刊介绍： Polymer Science, Series C (Selected Topics) is a journal published in collaboration with the Russian Academy of Sciences. Series C (Selected Topics) includes experimental and theoretical papers and reviews on the selected actual topics of macromolecular science chosen by the editorial board (1 issue a year). Submission is possible by invitation only. All journal series present original papers and reviews covering all fundamental aspects of macromolecular science. Contributions should be of marked novelty and interest for a broad readership. Articles may be written in English or Russian regardless of country and nationality of authors. All manuscripts are peer reviewed