Electro-Olfactograms in Humans in Response to Ortho- and Retronasal Chemosensory Stimulation

IF 1 4区医学 Q4 Neuroscience

Chemosensory Perception Pub Date : 2016-09-30 DOI:10.1007/s12078-016-9217-z

Thomas Hummel, Han-Seok Seo, Roberto Pellegrino, Stefan Heilmann

{"title":"Electro-Olfactograms in Humans in Response to Ortho- and Retronasal Chemosensory Stimulation","authors":"Thomas Hummel, Han-Seok Seo, Roberto Pellegrino, Stefan Heilmann","doi":"10.1007/s12078-016-9217-z","DOIUrl":null,"url":null,"abstract":"Ortho- and retronasal olfaction represent two aspects of a shared sensory system yet evoke different sensations. The differences between ortho- and retronasal olfaction have triggered a number of studies during the past years, which pointed towards a decreased sensitivity to odors presented through the retronasal olfactory pathway. Especially intensity was reported to be lower after retronasal olfactory stimulation. The aim of this study was to investigate how this compares to activation at the level of the olfactory epithelium in humans.Trigeminal (CO2) and olfactory (H2S, phenylethyl alcohol) stimuli were presented ortho- and retronasally. Electro-olfactograms (EOG) in response to chemosensory stimulation were recorded in 10 participants (6 women, 4 men, mean age 23.4?years).Typical EOGs were demonstrable after either orthonasal or retronasal stimulation across the stimulus qualities. Overall, EOG amplitudes to retronasal stimulation were smaller when compared to those to orthonasal stimulation, but a significant difference was obtained only in phenylethyl alcohol (p?=?0.048).The present data indicate that the perceptual differences between ortho- and retronasal olfaction may start at the level of the olfactory epithelium. The data support the idea that the intensity of physically identical stimuli is lower after retronasal stimulation compared to orthonasal stimulus presentation for both olfactory and trigeminal stimuli.The current electrophysiological results are in line with reported differences in psychophysical properties of retro- and orthonasal stimulations meaning that different sensations are elicit through these two channels although the same molecule is presented.","PeriodicalId":516,"journal":{"name":"Chemosensory Perception","volume":"10 4","pages":"114 - 118"},"PeriodicalIF":1.0000,"publicationDate":"2016-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12078-016-9217-z","citationCount":"13","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemosensory Perception","FirstCategoryId":"3","ListUrlMain":"https://link.springer.com/article/10.1007/s12078-016-9217-z","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Neuroscience","Score":null,"Total":0}

引用次数: 13

Abstract

Ortho- and retronasal olfaction represent two aspects of a shared sensory system yet evoke different sensations. The differences between ortho- and retronasal olfaction have triggered a number of studies during the past years, which pointed towards a decreased sensitivity to odors presented through the retronasal olfactory pathway. Especially intensity was reported to be lower after retronasal olfactory stimulation. The aim of this study was to investigate how this compares to activation at the level of the olfactory epithelium in humans.

Trigeminal (CO₂) and olfactory (H₂S, phenylethyl alcohol) stimuli were presented ortho- and retronasally. Electro-olfactograms (EOG) in response to chemosensory stimulation were recorded in 10 participants (6 women, 4 men, mean age 23.4?years).

Typical EOGs were demonstrable after either orthonasal or retronasal stimulation across the stimulus qualities. Overall, EOG amplitudes to retronasal stimulation were smaller when compared to those to orthonasal stimulation, but a significant difference was obtained only in phenylethyl alcohol (p?=?0.048).

The present data indicate that the perceptual differences between ortho- and retronasal olfaction may start at the level of the olfactory epithelium. The data support the idea that the intensity of physically identical stimuli is lower after retronasal stimulation compared to orthonasal stimulus presentation for both olfactory and trigeminal stimuli.

The current electrophysiological results are in line with reported differences in psychophysical properties of retro- and orthonasal stimulations meaning that different sensations are elicit through these two channels although the same molecule is presented.

Abstract Image

查看原文本刊更多论文

人对鼻前和鼻后化学感觉刺激反应的电嗅觉图

正鼻和后鼻嗅觉代表了共享感觉系统的两个方面，但唤起不同的感觉。在过去的几年里，正鼻嗅觉和后鼻嗅觉之间的差异引发了许多研究，这些研究指出，通过后鼻嗅觉途径呈现的气味敏感性降低。特别是经鼻后嗅觉刺激后，强度较低。本研究的目的是研究如何将其与人类嗅上皮水平的激活进行比较。三叉神经(CO2)和嗅觉(H2S，苯乙醇)刺激在鼻正侧和鼻后侧进行。记录了10名受试者(6名女性，4名男性，平均23.4岁)对化学感觉刺激反应的嗅电图(EOG)。在正鼻刺激或后鼻刺激后均可观察到典型的脑电图。总的来说，鼻后刺激的脑电图波幅比鼻前刺激的脑电图波幅要小，但只有苯乙醇的脑电图波幅有显著差异(p = 0.048)。目前的数据表明，鼻正嗅和鼻后嗅之间的感知差异可能始于嗅觉上皮水平。这些数据支持这样一种观点，即与嗅觉和三叉神经刺激相比，鼻后刺激后的物理上相同的刺激强度更低。目前的电生理结果与报道的反向和正鼻刺激的心理物理特性的差异一致，这意味着尽管呈现相同的分子，但通过这两个通道会引发不同的感觉。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Chemosensory Perception 农林科学-神经科学

CiteScore

2.50

自引率

0.00%

发文量

审稿时长

>36 weeks

期刊介绍： Coverage in Chemosensory Perception includes animal work with implications for human phenomena and explores the following areas: Identification of chemicals producing sensory response; Identification of sensory response associated with chemicals; Human in vivo response to chemical stimuli; Human in vitro response to chemical stimuli; Neuroimaging of chemosensory function; Neurological processing of chemoreception; Chemoreception mechanisms; Psychophysics of chemoperception; Trigeminal function; Multisensory perception; Contextual effect on chemoperception; Behavioral response to chemical stimuli; Physiological factors affecting and contributing to chemoperception; Flavor and hedonics; Memory and chemoperception.