A perspective on automated advanced continuous flow manufacturing units for the upgrading of biobased chemicals toward pharmaceuticals

IF 2 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY
Geoffroy Kaisin, Loïc Bovy, Yoann Joyard, Nicolas Maindron, Vincent Tadino, Jean-Christophe M. Monbaliu
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Abstract

Biomass is a renewable, almost infinite reservoir of a large diversity of highly functionalized chemicals. The conversion of biomass toward biobased platform molecules through biorefineries generally still lacks economic viability. Profitability could be enhanced through the development of new market opportunities for these biobased platform chemicals. The fine chemical industry, and more specifically the manufacturing of pharmaceuticals is one of the sectors bearing significant potential for these biobased building blocks to rapidly emerge and make a difference. There are, however, still many challenges to be dealt with before this market can thrive. Continuous flow technology and its integration for the upgrading of biobased platform molecules for the manufacturing of pharmaceuticals is foreseen as a game-changer. This perspective reflects on the main challenges relative to chemical, process, regulatory and supply chain-related burdens still to be addressed. The implementation of integrated continuous flow processes and their automation into modular units will help for tackling with these challenges.

Graphical abstract

Abstract Image

生物基化学品向药品升级的自动化先进连续流生产装置的展望
生物质是一种可再生的、几乎无限的高功能化化学物质的储存库。通过生物精炼厂将生物质转化为生物基平台分子通常仍然缺乏经济可行性。通过为这些生物基平台化学品开发新的市场机会,可以提高盈利能力。精细化工行业,更具体地说,药品制造是这些生物基构建模块迅速出现并发挥作用的巨大潜力的行业之一。然而,在这个市场蓬勃发展之前,仍有许多挑战需要解决。连续流技术及其集成升级的生物基平台分子用于制药被预见为游戏规则的改变者。这一观点反映了与化学、工艺、监管和供应链相关的负担有关的主要挑战仍有待解决。实现集成的连续流程及其自动化到模块化单元将有助于应对这些挑战。图形抽象
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来源期刊
Journal of Flow Chemistry
Journal of Flow Chemistry CHEMISTRY, MULTIDISCIPLINARY-
CiteScore
6.40
自引率
3.70%
发文量
29
审稿时长
>12 weeks
期刊介绍: The main focus of the journal is flow chemistry in inorganic, organic, analytical and process chemistry in the academic research as well as in applied research and development in the pharmaceutical, agrochemical, fine-chemical, petro- chemical, fragrance industry.
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