RNA Recognition by HIV-1 Tat and Rev

Abstract

HIV-1 Tat and Rev, two essential regulatory proteins, contain arginine-rich domains that are largely responsible for specific binding to their respective RNA sites, TAR and RRE. Structural studies demonstrate how these RNAs provide precise three-dimensional frameworks for protein binding.In vivo,Tat and Rev interact with additional cellular proteins to carry out their important roles in viral transcription and mRNA processing and transport.