Pseudoknots: A Vital Feature in Viral RNA

Birgit A.L.M. Deiman, Cornelis W.A. Pleij
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引用次数: 43

Abstract

The pseudoknot or “base-paired loop region” is a widespread structural motif in all kinds of viral RNAs. Detailed structures of hairpin-type pseudoknots, obtained by NMR, are now emerging, but it is still not clear which structural features are responsible for the different functions in processes like translation and replication. Especially noncoding regions are rich sources of pseudoknot structures, where they occur in domains like IRES elements and tRNA-like structures. But also its role in coding regions like in ribosomal -1 frameshifting and read-through is well established, although the precise mechanism of interference with the translational mechanism remains unknown.

假结:病毒RNA的重要特征
假结或“碱基配对环区”是各种病毒rna中广泛存在的结构基序。通过核磁共振获得的发簪型假结的详细结构现在正在出现,但仍然不清楚哪些结构特征负责翻译和复制等过程中的不同功能。特别是非编码区是假结结构的丰富来源,它们出现在IRES元件和trna样结构域中。但它在编码区,如核糖体-1的移框和读通中的作用也得到了很好的确定,尽管干扰翻译机制的确切机制尚不清楚。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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