Ruth M. Ruprecht , Timothy W. Baba , An Li , Seyoum Ayehunie , Yuwen Hu , Vladimir Liska , Robert Rasmussen , Prem L. Sharma
{"title":"Live attenuated HIV as a vaccine for AIDS: pros and cons","authors":"Ruth M. Ruprecht , Timothy W. Baba , An Li , Seyoum Ayehunie , Yuwen Hu , Vladimir Liska , Robert Rasmussen , Prem L. Sharma","doi":"10.1006/smvy.1996.0019","DOIUrl":null,"url":null,"abstract":"<div><p>Anti-HIV-1 vaccines must be safe and effective. In macaques, live attenuated simian immunodeficiency viruses have provided the best protection to date. Similar results were obtained earlier in murine leukemia virus systems in which protection correlated with cellular immunity but not with neutralizing antibodies. Attenuated primate lentiviruses tested thus far have been replication-impaired but may still harbor genetic determinants encoding virulence. Other safety issues concern insertional oncogenesis, genetic instability, vertical transmission and differential pathogenicity in adults and newborns, and viral persistence with possible reactivation during intercurrent illness. Long term safety studies are needed to assess the risks associated with live attenuated retrovirus vaccines.</p></div>","PeriodicalId":92955,"journal":{"name":"Seminars in virology","volume":"7 2","pages":"Pages 147-155"},"PeriodicalIF":0.0000,"publicationDate":"1996-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1006/smvy.1996.0019","citationCount":"12","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Seminars in virology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1044577396900190","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 12
Abstract
Anti-HIV-1 vaccines must be safe and effective. In macaques, live attenuated simian immunodeficiency viruses have provided the best protection to date. Similar results were obtained earlier in murine leukemia virus systems in which protection correlated with cellular immunity but not with neutralizing antibodies. Attenuated primate lentiviruses tested thus far have been replication-impaired but may still harbor genetic determinants encoding virulence. Other safety issues concern insertional oncogenesis, genetic instability, vertical transmission and differential pathogenicity in adults and newborns, and viral persistence with possible reactivation during intercurrent illness. Long term safety studies are needed to assess the risks associated with live attenuated retrovirus vaccines.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
