{"title":"Endogenous ecotropic and recombinant MCF mouse retroviral variation and escape from antiviral CTL","authors":"William R. Green, Patrick M. Smith","doi":"10.1006/smvy.1996.0007","DOIUrl":null,"url":null,"abstract":"<div><p>Mouse retroviruses cause a variety of diseases, including lymphoma/leukemia, and such experimental systems have served as useful models for analogous human diseases. Both ecotropic (mouse tropic) retroviruses (EMV) and polytropic recombinant mink cytopathic focus inducing (MCF) retroviruses have been studied for disease pathogenesis and as targets for host humoral and cellular immunity. Here, the cytolytic T lymphocyte (CTL) response to selected ecotropic and MCF retroviruses is defined, including an immunodominant CTL epitope located in the p15E transmembrane anchor envelope protein and several minor/subdominant epitopes. Also presented is evidence for retroviral escape from CTL by selection following genetic recombination, point mutation, and other strategies.</p></div>","PeriodicalId":92955,"journal":{"name":"Seminars in virology","volume":"7 1","pages":"Pages 49-60"},"PeriodicalIF":0.0000,"publicationDate":"1996-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1006/smvy.1996.0007","citationCount":"10","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Seminars in virology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1044577396900074","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 10
Abstract
Mouse retroviruses cause a variety of diseases, including lymphoma/leukemia, and such experimental systems have served as useful models for analogous human diseases. Both ecotropic (mouse tropic) retroviruses (EMV) and polytropic recombinant mink cytopathic focus inducing (MCF) retroviruses have been studied for disease pathogenesis and as targets for host humoral and cellular immunity. Here, the cytolytic T lymphocyte (CTL) response to selected ecotropic and MCF retroviruses is defined, including an immunodominant CTL epitope located in the p15E transmembrane anchor envelope protein and several minor/subdominant epitopes. Also presented is evidence for retroviral escape from CTL by selection following genetic recombination, point mutation, and other strategies.
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