Biosensors for detection of prostate cancer: a review

IF 3 4区医学 Q3 ENGINEERING, BIOMEDICAL

Biomedical Microdevices Pub Date : 2022-09-28 DOI:10.1007/s10544-022-00631-1

Sourav Sarkar, Manashjit Gogoi, Mrityunjoy Mahato, Abhijeet Balwantrao Joshi, Arup Jyoti Baruah, Prashant Kodgire, Polina Boruah

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引用次数: 5

Abstract

Diagnosis of prostate cancer (PC) has posed a challenge worldwide due to the sophisticated and costly diagnostics tools, which include DRE, TRUS, GSU, PET/CT scan, MRI, and biopsy. These diagnostic techniques are very helpful in the detection of PCs; however, all the techniques have their serious limitations. Biosensors are easier to fabricate and do not require any cutting-edge technology as required for other imaging techniques. In this regard, point-of-care (POC) biosensors are important due to their portability, convenience, low cost, and fast procedure. This review explains the various existing diagnostic tools for the detection of PCs and the limitation of these methods. It also focuses on the recent studies on biosensors technologies as an alternative to the conventional diagnostic techniques for the detection of PCs.

Graphical abstract

Abstract Image

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生物传感器检测前列腺癌的研究进展

前列腺癌(PC)的诊断在全球范围内都是一个挑战，因为诊断工具复杂而昂贵，包括DRE、TRUS、GSU、PET/CT扫描、MRI和活检。这些诊断技术对pc的检测非常有帮助;然而，所有的技术都有其严重的局限性。生物传感器更容易制造，并且不需要像其他成像技术那样需要任何尖端技术。在这方面，即时护理(POC)生物传感器因其便携性、便利性、低成本和快速操作而非常重要。这篇综述解释了各种现有的诊断工具的检测pc和这些方法的局限性。它还重点介绍了生物传感器技术作为检测pc的传统诊断技术的替代方法的最新研究。图形抽象

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomedical Microdevices 工程技术-工程：生物医学

CiteScore

6.90

自引率

3.60%

发文量

审稿时长

6 months

期刊介绍： Biomedical Microdevices: BioMEMS and Biomedical Nanotechnology is an interdisciplinary periodical devoted to all aspects of research in the medical diagnostic and therapeutic applications of Micro-Electro-Mechanical Systems (BioMEMS) and nanotechnology for medicine and biology. General subjects of interest include the design, characterization, testing, modeling and clinical validation of microfabricated systems, and their integration on-chip and in larger functional units. The specific interests of the Journal include systems for neural stimulation and recording, bioseparation technologies such as nanofilters and electrophoretic equipment, miniaturized analytic and DNA identification systems, biosensors, and micro/nanotechnologies for cell and tissue research, tissue engineering, cell transplantation, and the controlled release of drugs and biological molecules. Contributions reporting on fundamental and applied investigations of the material science, biochemistry, and physics of biomedical microdevices and nanotechnology are encouraged. A non-exhaustive list of fields of interest includes: nanoparticle synthesis, characterization, and validation of therapeutic or imaging efficacy in animal models; biocompatibility; biochemical modification of microfabricated devices, with reference to non-specific protein adsorption, and the active immobilization and patterning of proteins on micro/nanofabricated surfaces; the dynamics of fluids in micro-and-nano-fabricated channels; the electromechanical and structural response of micro/nanofabricated systems; the interactions of microdevices with cells and tissues, including biocompatibility and biodegradation studies; variations in the characteristics of the systems as a function of the micro/nanofabrication parameters.