The role of phosphoinositides in mast cell signalling

Richard D. Byrne, B. Larijani
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引用次数: 3

Abstract

The release of pre-formed mediators such as histamine from mast cells and basophils is an integral part of the normal immune response to infection by parasites. This exocytosis is also characteristic response in a number of disease states including asthma, which, due to their prevalence in western society are becoming of increasing clinical importance. In an effort to tackle this growing problem much work has gone into unlocking the mechanisms through which mast cells function in health and disease. To date we have learned a lot about the various proteins that regulate degranulation. However, our knowledge on the contribution of lipids to this process is less clear. This review will discuss the role of phospholipids, particularly the phosphoinositides (PIs) in the processes that regulate mast cell exocytosis.
磷酸肌苷在肥大细胞信号传导中的作用
肥大细胞和嗜碱性细胞释放预先形成的介质,如组胺,是对寄生虫感染的正常免疫反应的一个组成部分。这种胞吐也是许多疾病状态的特征性反应,包括哮喘,由于它们在西方社会的流行,正变得越来越重要。为了解决这一日益严重的问题,许多工作都在解开肥大细胞在健康和疾病中发挥作用的机制。到目前为止,我们已经了解了很多关于调节脱颗粒的各种蛋白质。然而,我们对脂质在这一过程中所起的作用的了解还不太清楚。本文将讨论磷脂,特别是磷酸肌苷(pi)在调节肥大细胞胞吐过程中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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