Augmentation of selective serotonin reuptake inhibitor antidepressant efficacy with pindolol and the relevance of 5HT1A autoreceptors

Abstract

Any discussion of antidepressants and their ability to inhibit monoamine uptake necessarily embodies an abundant literature, especially when focused on potential alterations in the function of either serotonergic or noradrenergic systems. However, with due respect to the multitude of studies published during the last 30 years, the present review concentrates on recent microdialysis observations in rats and the rather swift transfer of preclinical information to the clinic for hypothesis testing. Anxiety 2:149–152 (1996). © 1996 Wiley-Liss, Inc.