In silico experiments of intimal hyperplasia development: disendothelization in an axisymmetric idealized artery

IF 3 3区医学 Q2 BIOPHYSICS

Biomechanics and Modeling in Mechanobiology Pub Date : 2023-04-28 DOI:10.1007/s10237-023-01720-7

Jérôme Jansen, Xavier Escriva, Fabien Godeferd, Patrick Feugier

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Abstract

We use in silico experiments to study the role of the hemodynamics and of the type of disendothelization on the physiopathology of intimal hyperplasia. We apply a multiscale bio-chemo-mechanical model of intimal hyperplasia on an idealized axisymmetric artery that suffers two kinds of disendothelizations. The model predicts the spatio-temporal evolution of the lesions development, initially localized at the site of damages, and after few days displaced downstream of the damaged zones, these two stages being observed whatever the kind of damage. Considering macroscopic quantities, the model sensitivity to pathology-protective and pathology-promoting zones is qualitatively consistent with experimental findings. The simulated pathological evolutions demonstrate the central role of two parameters: (a) the initial damage shape on the morphology of the incipient stenosis, and (b) the local wall shear stresses on the overall spatio-temporal dynamics of the lesion.

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内膜增生发育的硅片实验:轴对称理想化动脉的去内皮化

我们利用计算机实验来研究血流动力学和去内皮化类型在内膜增生的生理病理中的作用。我们应用多尺度生物化学力学模型内膜增生的理想轴对称动脉遭受两种脱内皮化。该模型预测了损伤发展的时空演变，最初局限于损伤部位，几天后向损伤区域下游转移，无论哪种损伤都可以观察到这两个阶段。考虑宏观量，模型对病理保护区和病理促进区敏感性与实验结果定性一致。模拟的病理演变证明了两个参数的核心作用:(a)初始损伤形状对早期狭窄形态的影响，以及(b)局部壁剪切应力对病变整体时空动态的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomechanics and Modeling in Mechanobiology 工程技术-工程：生物医学

CiteScore

7.10

自引率

8.60%

发文量

119

审稿时长

6 months

期刊介绍： Mechanics regulates biological processes at the molecular, cellular, tissue, organ, and organism levels. A goal of this journal is to promote basic and applied research that integrates the expanding knowledge-bases in the allied fields of biomechanics and mechanobiology. Approaches may be experimental, theoretical, or computational; they may address phenomena at the nano, micro, or macrolevels. Of particular interest are investigations that (1) quantify the mechanical environment in which cells and matrix function in health, disease, or injury, (2) identify and quantify mechanosensitive responses and their mechanisms, (3) detail inter-relations between mechanics and biological processes such as growth, remodeling, adaptation, and repair, and (4) report discoveries that advance therapeutic and diagnostic procedures. Especially encouraged are analytical and computational models based on solid mechanics, fluid mechanics, or thermomechanics, and their interactions; also encouraged are reports of new experimental methods that expand measurement capabilities and new mathematical methods that facilitate analysis.