{"title":"FDA Black Box Warning for SSRI: Reexamining the Role of High-Functioning Autism as a Confounder","authors":"Mayank Gupta, Nihit Gupta","doi":"10.1007/s41252-022-00301-6","DOIUrl":null,"url":null,"abstract":"<div><h2>Abstract \n</h2><div><p>It is two decades since the start of controversy around the FDA’s warnings of SSRI use in children and adolescents. A detailed review of these debates provides information on many serious methodological limitations, omissions, and commissions. In the last decade, the knowledge of highly comorbid conditions with MDD like ASD has grown exponentially. The higher-than-ever prevalence and diagnostic overshadowing in higher functioning ASD are now widely accepted; likewise, late and missed diagnoses are common and more in females with HF-ASD. The FDA signal has clinical implications, and if a small proportion of undiagnosed ASD comorbid with MDD was confounded in the data remains unanswered. A scientific inquiry is needed to understand the relationship between ASD, affective illness, and suicide.</p></div></div>","PeriodicalId":36163,"journal":{"name":"Advances in Neurodevelopmental Disorders","volume":null,"pages":null},"PeriodicalIF":1.3000,"publicationDate":"2022-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in Neurodevelopmental Disorders","FirstCategoryId":"1085","ListUrlMain":"https://link.springer.com/article/10.1007/s41252-022-00301-6","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"EDUCATION, SPECIAL","Score":null,"Total":0}
引用次数: 1
Abstract
Abstract
It is two decades since the start of controversy around the FDA’s warnings of SSRI use in children and adolescents. A detailed review of these debates provides information on many serious methodological limitations, omissions, and commissions. In the last decade, the knowledge of highly comorbid conditions with MDD like ASD has grown exponentially. The higher-than-ever prevalence and diagnostic overshadowing in higher functioning ASD are now widely accepted; likewise, late and missed diagnoses are common and more in females with HF-ASD. The FDA signal has clinical implications, and if a small proportion of undiagnosed ASD comorbid with MDD was confounded in the data remains unanswered. A scientific inquiry is needed to understand the relationship between ASD, affective illness, and suicide.
期刊介绍：
Advances in Neurodevelopmental Disorders publishes high-quality research in the broad area of neurodevelopmental disorders across the lifespan. Study participants may include individuals with:Intellectual and developmental disabilitiesGlobal developmental delayCommunication disordersLanguage disordersSpeech sound disordersChildhood-onset fluency disorders (e.g., stuttering)Social (e.g., pragmatic) communication disordersUnspecified communication disordersAutism spectrum disorder (ASD)Attention-deficit/hyperactivity disorder (ADHD), specified and unspecifiedSpecific learning disordersMotor disordersDevelopmental coordination disordersStereotypic movement disorderTic disorders, specified and unspecifiedOther neurodevelopmental disorders, specified and unspecifiedPapers may also include studies of participants with neurodegenerative disorders that lead to a decline in intellectual functioning, including Alzheimer’s disease, amyotrophic lateral sclerosis, Creutzfeldt-Jakob disease, vascular dementia, Lewy body dementia, frontotemporal dementia, corticobasal degeneration, Huntington’s disease, and progressive supranuclear palsy. The journal includes empirical, theoretical and review papers on a large variety of issues, populations, and domains, including but not limited to: diagnosis; incidence and prevalence; and educational, pharmacological, behavioral and cognitive behavioral, mindfulness, and psychosocial interventions across the life span. Animal models of basic research that inform the understanding and treatment of neurodevelopmental disorders are also welcomed. The journal is multidisciplinary and multi-theoretical, and encourages research from multiple specialties in the social sciences using quantitative and mixed-method research methodologies.
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