Simultaneous determination of enthalpy of mixing and reaction using milli-scale continuous flow calorimetry

IF 2 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Journal of Flow Chemistry Pub Date : 2022-07-27 DOI:10.1007/s41981-022-00237-x

Finn L. Steinemann, David P. Rütti, Marlies Moser, Alain G. Georg, Daniel M. Meier

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引用次数: 1

Abstract

A simultaneous determination of the enthalpy of mixing and reaction in a scalable continuous milli-scale flow calorimeter is investigated. As obtained calorimetric data is pivotal for the safety assessment of chemical reactions and processes. The acid-catalysed selective, homogeneous hydrolysis of acetic anhydride with half-lives from a few seconds to a few minutes is investigated as a model reaction. For the enthalpy of mixing 7.2 ± 2.8 kJ/mol and for the enthalpy of reaction −60.8 ± 2.5 kJ/mol were determined. For reactions that show complete conversion in the continuous reactor, a technique is introduced to further improve the accuracy of the reaction enthalpy determination. Thereby, the resolution of the observed temperature profile is increased by measuring the profile at different flow rates. Applying this procedure, the reaction enthalpy of −62.5 kJ/mol was determined which is in good agreement with literature values for this model reaction.

Graphical abstract

Abstract Image

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用毫米级连续流量热法同时测定混合焓和反应焓

研究了在可伸缩连续毫尺度流动量热计中同时测定混合焓和反应焓的方法。所获得的量热数据对于化学反应和过程的安全性评价是至关重要的。研究了半衰期从几秒到几分钟的醋酸酐选择性均相水解的模型反应。混合焓为7.2±2.8 kJ/mol，反应焓为−60.8±2.5 kJ/mol。对于在连续反应器中表现完全转化的反应，介绍了一种进一步提高反应焓测定精度的技术。因此，通过测量不同流速下的温度分布，可以提高所观察到的温度分布的分辨率。用此方法测定了反应焓为- 62.5 kJ/mol，与文献值吻合较好。图形抽象

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来源期刊

Journal of Flow Chemistry CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

6.40

自引率

3.70%

发文量

审稿时长

>12 weeks

期刊介绍： The main focus of the journal is flow chemistry in inorganic, organic, analytical and process chemistry in the academic research as well as in applied research and development in the pharmaceutical, agrochemical, fine-chemical, petro- chemical, fragrance industry.