Relationship between the expression level of miRNA-4485 and the severity of depressive symptoms in major depressive disorder patients

IF 2.5 4区 医学 Q2 PSYCHIATRY
Hong-tao Song , Xin-yang Sun , Wei Niu , Qiao-li Zhang , Li-yi Zhang , Ai-fang Zhong
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Abstract

Background and objectives

Despite the growing pieces of evidence on the relationship between the altered expression level of miRNAs and major depressive disorder (MDD), few studies have focused on the relationship between the altered expression of miRNAs and the severity of depressive symptoms. This study aimed to investigate the relationship between the expression level of miRNA-4485 and the severity of depressive symptoms in major depressive disorder (MDD) patients.

Methods

Eighty MDD patients without antidepressants and 45 healthy controls were placed and tested for the expression level of miRNA-4485 using quantitative RT‒PCR. At the same time, the Hamilton Depression Scale (HAMD) was used to assess depression symptoms for MDD patients. Twenty-nine out of 80 MDD patients were selected for miRNA expression level testing and symptomatology assessments before and after three weeks of treatment.

Results

The expression level of miRNA-4485 in the MDD group was significantly overexpressed compared to that in healthy controls (P < 0.05), and the expression level of miRNA-4485 in the higher HAMD group was also much higher than that in the lower HAMD group and healthy controls (P < 0.05). The expression level of miRNA-4485 in MDD patients was negatively correlated with HAMD total score, anxiety/somatization, and bodyweight factor score (P < 0.05), accounting for 9.4%, 12.4% and 5.7%, respectively. MiRNA-4485 significantly predicted MDD and the severity of depressive symptoms (P < 0.05). Compared with that before treatment, the expression level of miRNA-4485 was significantly downregulated after treatment, while the patient's depressive symptoms were improved (p < 0.05). The improvement in depressive symptoms was positively correlated with the downregulation of miRNA-4485, which could significantly predict the effects of antidepressant treatment on MDD (P < 0.05).

Conclusion

MiRNA-4485, which is significantly related to depressive symptoms and its improvement, could be a valuable biomarker or drug target to predict MDD, the severity of depressive symptoms and the effects of antidepressant treatment on MDD.

miRNA-4485表达水平与重度抑郁症患者抑郁症状严重程度的关系
背景和目的尽管越来越多的证据表明miRNA表达水平的改变与重度抑郁症(MDD)之间的关系,但很少有研究关注miRNA表达的改变与抑郁症症状严重程度之间的关系。本研究旨在探讨严重抑郁障碍(MDD)患者中miRNA-4485的表达水平与抑郁症状严重程度之间的关系。方法对80例未服用抗抑郁药的MDD患者和45名健康对照进行定量RT-PCR检测miRNA-4485的表达水平。同时,汉密尔顿抑郁量表(HAMD)用于评估MDD患者的抑郁症状。从80名MDD患者中选择29名在治疗前和治疗三周后进行miRNA表达水平测试和症状评估。结果MDD组miRNA-4485的表达水平显著高于健康对照组(P<0.05),高HAMD组的miRNA-4485表达水平也远高于低HAMD组和健康对照组(P<;0.05)。MDD患者的miRNA44485表达水平与HAMD总分、焦虑/躯体化和体重因子评分呈负相关(P<),分别占9.4%、12.4%和5.7%。MiRNA-4485可显著预测MDD和抑郁症状的严重程度(P<;0.05)。与治疗前相比,MiRNA-4485%的表达水平在治疗后显著下调,而患者的抑郁症状有所改善(P<)。抑郁症状的改善与MiRNA-44八十五的下调呈正相关,结论miRNA-4485与抑郁症状及其改善显著相关,可作为预测MDD、抑郁症状严重程度和抗抑郁治疗对MDD影响的有价值的生物标志物或药物靶点。
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来源期刊
CiteScore
2.90
自引率
0.00%
发文量
40
审稿时长
43 days
期刊介绍: The European journal of psychiatry is a quarterly publication founded in 1986 and directed by Professor Seva until his death in 2004. It was originally intended to report “the scientific activity of European psychiatrists” and “to bring about a greater degree of communication” among them. However, “since scientific knowledge has no geographical or cultural boundaries, is open to contributions from all over the world”. These principles are maintained in the new stage of the journal, now expanded with the help of an American editor.
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