Synthesis and biological activities of benzothiazole derivatives: A review

Abstract

The research and development of benzothiazole derivatives have gained significant interest in recent years due to their diverse range of pharmacological activities. Benzothiazole-based compounds have been found to be effective in the treatment of various diseases including cancer, microbial infections and cardiovascular diseases. The synthesis of benzothiazole derivatives has been an active area of research, and several synthetic methods have been developed to access these compounds. The development of new.synthetic approaches and the modification of existing methods have allowed for the creation of novel scaffolds with improved biological properties and specificity. Benzothiazole derivatives have exhibited a wide range of biological activities including antitumor, antibiotic, antifungal, antimicrobial, HIV–I protease inhibition, and antiarteriosclerosis activities. The exploration of the pharmacological properties of benzothiazole derivatives continues to be an exciting area of research with the potential for the discovery of new drugs and therapies. Present review of benzothiazole and its derivatives provides a comprehensive overview of their synthesis and biological activities. This review will serve as a useful resource for researchers working in the field of synthetic chemistry and drug discovery, and it is expected to inspire further research and development of benzothiazole-based compounds with enhanced pharmacological properties.