{"title":"Acute pontine tumefactive multiple sclerosis","authors":"Yalda Nikanpour , M. Toledano , W. Oliver Tobin","doi":"10.1016/j.nerep.2023.100179","DOIUrl":null,"url":null,"abstract":"<div><p>A 20-year-old woman presented with ataxia, right-sided hemiparesis, headache, and fever. Brain MRI showed a large non enhancing pontine T2 hyperintense lesion with slight diffusion restriction. Her clinical condition progressed to quadriparesis, dysarthria and ophthalmoplegia. The patient was diagnosed with tumefactive multiple sclerosis. She had a positive response to plasma exchange and cyclophosphamide, and ultimately returned to running at 1 year follow up. De novo tumefactive demyelination, diagnosis, and indications for aggressive treatment are discussed.</p></div>","PeriodicalId":100950,"journal":{"name":"Neuroimmunology Reports","volume":"4 ","pages":"Article 100179"},"PeriodicalIF":0.0000,"publicationDate":"2023-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neuroimmunology Reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2667257X23000177","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
A 20-year-old woman presented with ataxia, right-sided hemiparesis, headache, and fever. Brain MRI showed a large non enhancing pontine T2 hyperintense lesion with slight diffusion restriction. Her clinical condition progressed to quadriparesis, dysarthria and ophthalmoplegia. The patient was diagnosed with tumefactive multiple sclerosis. She had a positive response to plasma exchange and cyclophosphamide, and ultimately returned to running at 1 year follow up. De novo tumefactive demyelination, diagnosis, and indications for aggressive treatment are discussed.
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