{"title":"Organoid cultures as model systems to study disorders of the human endometrium and placenta","authors":"Ashley Moffett","doi":"10.1016/j.ogrm.2023.06.004","DOIUrl":null,"url":null,"abstract":"<div><p><span>Studying the underlying pathogenesis of disorders of the endometrium<span><span> and of human pregnancy is challenging due to the lack of good in vivo and animal models. The development of organoid cultures has provided new opportunities to perform experiments in humans that recapitulate the in vivo situation. Endometrial organoids can be derived from tissues or menstrual fluid and respond robustly to ovarian hormones. Placental trophoblast organoids can only be generated from </span>placentas<span> under 9 weeks gestation. These assemble to form the structure of a placental villus. Modification of the culture conditions drives them to differentiate to the invading trophoblast that functions to transform the uterine </span></span></span>spiral arteries<span>. This process is critical for pregnancy success. These model systems will be transformative in understanding the biology of the female reproductive tract in health and disease.</span></p></div>","PeriodicalId":53410,"journal":{"name":"Obstetrics, Gynaecology and Reproductive Medicine","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Obstetrics, Gynaecology and Reproductive Medicine","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1751721423000957","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
Studying the underlying pathogenesis of disorders of the endometrium and of human pregnancy is challenging due to the lack of good in vivo and animal models. The development of organoid cultures has provided new opportunities to perform experiments in humans that recapitulate the in vivo situation. Endometrial organoids can be derived from tissues or menstrual fluid and respond robustly to ovarian hormones. Placental trophoblast organoids can only be generated from placentas under 9 weeks gestation. These assemble to form the structure of a placental villus. Modification of the culture conditions drives them to differentiate to the invading trophoblast that functions to transform the uterine spiral arteries. This process is critical for pregnancy success. These model systems will be transformative in understanding the biology of the female reproductive tract in health and disease.
期刊介绍：
Obstetrics, Gynaecology and Reproductive Medicine is an authoritative and comprehensive resource that provides all obstetricians, gynaecologists and specialists in reproductive medicine with up-to-date reviews on all aspects of obstetrics and gynaecology. Over a 3-year cycle of 36 issues, the emphasis of the journal is on the clear and concise presentation of information of direct clinical relevance to specialists in the field and candidates studying for MRCOG Part II. Each issue contains review articles on obstetric and gynaecological topics. The journal is invaluable for obstetricians, gynaecologists and reproductive medicine specialists, in their role as trainers of MRCOG candidates and in keeping up to date across the broad span of the subject area.
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