Autoantibody-negative but probable pediatric autoimmune encephalitis following COVID-19 vaccination: A case report

Neuroimmunology Reports Pub Date : 2023-01-01 DOI:10.1016/j.nerep.2023.100173

Masato Ando, Kunihiro Matsunami, Sotaro Yuzawa, Tatsuya Sakashita, Hiroaki Murakami, Shuji Kuwabara, Eiji Matsukuma, Atsushi Imamura

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引用次数: 1

Abstract

Background

Large-scale vaccination against the novel coronavirus (COVID-19) occurred globally at an unprecedented pace. Sporadic cases of autoimmune encephalitis (AE) have been reported following COVID-19 vaccination, mainly in adults.

Case report

A 14-year-old girl developed altered mental status and was brought to our emergency department because of a seizure 19 days after receiving the third dose of COVID-19 vaccination. She was treated with steroid pulse therapy and fully recovered. The diagnosis of probable autoantibody-negative AE was finally made.

Conclusion

This case met the criteria for probable autoantibody-negative AE in children, as well as adults. Because of the temporal association and absence of another identifiable cause, her conditions may have been triggered by the COVID-19 vaccination. To our knowledge, this is the first published pediatric case of autoantibody-negative but probable AE following COVID-19 vaccination.

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新冠肺炎疫苗接种后自身抗体阴性但可能的儿童自身免疫性脑炎：一例报告

背景新型冠状病毒（新冠肺炎）大规模疫苗接种在全球范围内以前所未有的速度进行。新冠肺炎疫苗接种后报告了零星的自身免疫性脑炎（AE）病例，主要发生在成年人中。病例报告一名14岁女孩在接种第三剂新冠肺炎疫苗19天后出现精神状态改变，因癫痫发作被带到我们的急诊室。她接受了类固醇脉冲治疗并完全康复。最终诊断为可能的自身抗体阴性AE。结论该病例符合儿童和成人自身抗体阴性AE的标准。由于时间相关性和缺乏另一个可识别的原因，她的病情可能是由新冠肺炎疫苗接种引发的。据我们所知，这是新冠肺炎疫苗接种后首次公布的自身抗体阴性但可能发生AE的儿科病例。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Neuroimmunology Reports

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