Exploring potential of exosomes drug delivery system in the treatment of cancer: Advances and prospective

Q2 Medicine
Medicine in Drug Discovery Pub Date : 2023-12-01 Epub Date: 2023-10-12 DOI:10.1016/j.medidd.2023.100163
Deepika Yadav, Rishabha Malviya
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引用次数: 0

Abstract

Exosomes are vital for cellular communication and the transfer of materials between cells. Recently, it has been shown that nanoparticles may be used as diagnostic indicators and as a potential medicine delivery strategy due to their nanoscale size and capacity to carry biological components to target cells. Exosomes have the potential to be an appealing and practical approach for drug administration in cancer treatment due to their biocompatibility, high stability, favoured tumour homing, and adjustable targeting efficacy. While exosomes have properties that make them useful for transporting bioactive compounds, the gap between our present understanding of exosome biology and the most optimal condition for their use remains. The rationale for using exosomes as a drug delivery strategy, their production and purification, bioengineering and targeting, uptake and distribution, efficacy, immune response, and other factors will all be discussed in this study. Modern methods are required for observing, categorising, and sorting exosome diversity. Improvements in nanotechnology and our knowledge of exosome biology will undoubtedly speed up the field's medical uses.

Abstract Image

探索外泌体给药系统治疗癌症的潜力:进展与展望
外泌体对细胞通讯和细胞间物质转移至关重要。最近,研究表明,由于纳米颗粒的纳米尺寸和携带生物成分到靶细胞的能力,纳米颗粒可以用作诊断指标和潜在的药物递送策略。外泌体由于其生物相容性、高稳定性、有利于肿瘤归位和可调节的靶向疗效,有可能成为癌症治疗中一种有吸引力和实用的药物管理方法。虽然外泌体具有可用于运输生物活性化合物的特性,但我们目前对外泌体生物学的理解与使用外泌体的最佳条件之间仍然存在差距。本研究将讨论使用外泌体作为药物递送策略的原理、它们的生产和纯化、生物工程和靶向、吸收和分布、疗效、免疫反应和其他因素。观察、分类和分类外来体多样性需要现代方法。纳米技术的进步和我们对外来体生物学的了解无疑将加速该领域的医学应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Medicine in Drug Discovery
Medicine in Drug Discovery Medicine-Pharmacology (medical)
CiteScore
8.30
自引率
0.00%
发文量
30
审稿时长
21 days
期刊介绍:
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