The role of SARS-COV-2 infection in promoting abnormal immune response and sepsis: A comparison between SARS-COV-2-related sepsis and sepsis from other causes

Infectious Medicine Pub Date : 2023-09-01 DOI:10.1016/j.imj.2023.04.006

Andrea Piccioni , Laura Franza , Federico Rosa , Marcello Candelli , Marcello Covino , Michela Ferrara , Gianpietro Volonnino , Giuseppe Bertozzi , Maria Vittoria Zamponi , Aniello Maiese , Gabriele Savioli , Francesco Franceschi , Raffaele La Russa

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引用次数: 1

Abstract

Background

COVID-19 caused by SARS-CoV-2 virus is characterized by respiratory compromise and immune system involvement, even leading to serious disorders, such as cytokine storm.

Methods

We then conducted a literature review on the topic of sepsis and covid-19, and in parallel conducted an experimental study on the histological finding of patients who died from SARS-Covid 19 infection and a control group.

Results

Sepsis associated with covid-19 infection has some similarities and differences from that from other causes.

Conclusion

In this paper the complex interplay between the 2 disorders was discussed, focusing on the similarities and on the effect that one could have on the other. A preliminary experimental section that demonstrates the multisystemic involvement in subjects who die from SARS-CoV-2 is also proposed.

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严重急性呼吸系统综合征冠状病毒2型感染在促进异常免疫反应和败血症中的作用：严重急性呼吸系综合征冠状病毒-2型相关败血症和其他原因败血症的比较

背景由严重急性呼吸系统综合征冠状病毒2型引起的新冠肺炎以呼吸系统损害和免疫系统受累为特征，甚至会导致严重的疾病，如细胞因子风暴。方法对脓毒症和新冠肺炎进行文献回顾，同时对死于SARS-covid 19感染的患者和对照组的组织学发现进行实验研究。结果新冠肺炎感染脓毒症与其他病因有一定的异同。结论本文讨论了这两种疾病之间复杂的相互作用，重点讨论了它们的相似性以及其中一种可能对另一种产生的影响。还提出了一个初步实验部分，证明死于严重急性呼吸系统综合征冠状病毒2型的受试者的多系统参与。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Infectious Medicine

CiteScore

1.40

自引率

0.00%

发文量