Effects of dietary PUFA patterns and FADS genotype on breast milk PUFAs in Chinese lactating mothers.

IF 3.3 3区 医学 Q2 GENETICS & HEREDITY
Wen-Hui Xu, Yi-Ru Chen, Hui-Min Tian, Yi-Fei Chen, Jia-Yu Gong, Hai-Tao Yu, Guo-Liang Liu, Lin Xie
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引用次数: 0

Abstract

Background: Breastfeeding affects the growth and development of infants, and polyunsaturated fatty acids (PUFAs) play a crucial role in this process. To explore the factors influencing the PUFA concentration in breast milk, we conducted research on two aspects: dietary fatty acid patterns and single nucleotide polymorphisms (SNPs) in maternal fatty acid desaturase genes.

Methods: Three hundred seventy Chinese Han lactating mothers were recruited. A dietary semi-quantitative food frequency questionnaire (FFQ) was used to investigate the dietary intake of lactating mothers from 22 to 25 days postpartum for 1 year. Meanwhile, breast milk samples were collected from the participants and tested for the concentrations of 8 PUFAs and 10 SNP genotypes. We sought to determine the effect of dietary PUFA patterns and SNPs on breast milk PUFAs. We used SPSS 24.0 statistical software for data analysis. Statistical tests were all bilateral tests, with P < 0.05 as statistically significant.

Results: Under the same dietary background, PUFA contents in breast milk expressed by most major allele homozygote mothers tended to be higher than that expressed by their counterparts who carried minor allele genes. Moreover, under the same gene background, PUFA contents in breast milk expressed by the mother's intake of essential PUFA pattern tended to be higher than that expressed by their counterparts who took the other two kinds of dietary.

Conclusions: Our study suggests that different genotypes and dietary PUFA patterns affect PUFA levels in breast milk. We recommend that lactating mothers consume enough essential fatty acids to ensure that their infants ingest sufficient PUFAs.

Abstract Image

膳食PUFA模式和FADS基因型对中国泌乳母亲母乳PUFA的影响。
背景:母乳喂养影响婴儿的生长发育,而多不饱和脂肪酸(PUFA)在这一过程中起着至关重要的作用。为了探讨影响母乳中PUFA浓度的因素,我们从饮食脂肪酸模式和母体脂肪酸去饱和酶基因单核苷酸多态性两个方面进行了研究。方法:选取370名中国汉族哺乳期母亲。采用膳食半定量食物频率问卷(FFQ)对哺乳期母亲产后22-25天的膳食摄入量进行了为期1年的调查。同时,从参与者身上采集母乳样本,并测试8种PUFA和10种SNP基因型的浓度。我们试图确定饮食PUFA模式和SNPs对母乳PUFA的影响。我们使用SPSS 24.0统计软件进行数据分析。统计学检验均为双侧检验,P 结果:在相同的饮食背景下,大多数主要等位基因纯合的母亲在母乳中表达的PUFA含量往往高于携带次要等位基因的母亲。此外,在相同的基因背景下,母亲摄入必需PUFA模式所表达的母乳中PUFA含量往往高于摄入其他两种饮食的母亲所表达的含量。结论:我们的研究表明,不同的基因型和饮食PUFA模式会影响母乳中PUFA的水平。我们建议哺乳期母亲摄入足够的必需脂肪酸,以确保婴儿摄入足够的PUFA。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Genes and Nutrition
Genes and Nutrition 生物-遗传学
CiteScore
6.60
自引率
0.00%
发文量
14
审稿时长
6-12 weeks
期刊介绍: This journal examines the relationship between genetics and nutrition, with the ultimate goal of improving human health. It publishes original research articles and review articles on preclinical research data coming largely from animal, cell culture and other experimental models as well as critical evaluations of human experimental data to help deliver products with medically proven use.
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